AI Article Synopsis
- TLRs typically recognize microorganisms to trigger host defenses, but their roles in physiology and disease are more complex than previously thought.
- Research suggests that TLRs can also recognize endogenous (internally produced) substances, expanding their functional scope.
- The study highlights an endogenous agonist for TLR4 and discusses potential mechanisms for regulating its activity.
Article Abstract
TLRs are usually thought to recognize substances produced by microorganisms and thus, to initiate host defenses. This concept, however, fails to explain some functions of this family of receptors. Recognition of endogenous substances may explain the broader functions of TLRs in physiology and disease. Activation of TLRs by endogenous substances necessitates vigorous control of the function of the receptors. This communication will summarize a line of research, which points to an endogenous agonist for TLR4 and a putative mechanism for controlling the function of that receptor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1189/jlb.1206752 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry].
Se Pu
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;3. University of Chinese Academy of Sciences, Beijing 100049, China.
Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides.
View Article and Find Full Text PDF[Distribution Characteristic and Environment Response of DOM in Different Regions of Northern City].
Huan Jing Ke Xue
January 2025
School of Civil Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.
To explore the source information and composition characteristics of dissolved organic matter （DOM） in different regions of water bodies in northern cities, considering the urban water system of Shijiazhuang, Hebei Province as an example, ultraviolet-visible spectroscopy （UV-vis） and three-dimensional fluorescence parallel factor analysis （EEM-PARAFAC） were used to explain the optical parameters, abundance, and proportion of different components of DOM in water bodies of different regions. The results showed that： ① The concentrations of NO-N, NO-N, NH-N, TN, TP, and COD in the upstream were significantly lower than those in urban water bodies and downstream （<0.01）, and TSI increased after the water entered the city.
View Article and Find Full Text PDFMicroneedle-Based Electrochemical Array Patch for Ultra-Antifouling and Ultra-Anti-Interference Monitoring of Subcutaneous Oxygen.
Anal Chem
December 2024
School of Science, Harbin Institute of Technology, Shenzhen 518055, China.
Oxygen saturation is a crucial indicator in the management of various diseases and in preoperative diagnosis, and the detection of oxygen content is valuable in guiding clinical treatment. However, as the classical and dominant oxygen detection strategies, current photoelectric oximeters and electrochemical-based blood gas analyzers often suffer from significant interindividual variation and poor compliance, respectively. In recent years, wearable microneedles (MNs) for analyzing biomarkers in interstitial fluid (ISF) have received great attention and recognition mainly for the reason that the content of the substances distributed in ISF has a better correlation with that in blood circulation compared with other body fluids such as sweat and saliva.
View Article and Find Full Text PDFStudy on the physiological mechanism and transcriptional regulatory network of early fruit development in Gleditsia sinensis Lam. (Fabaceae).
BMC Plant Biol
December 2024
College of forestry, Guizhou University, Guiyang550025, Guizhou, China.
Background: Gleditsia sinensis Lam. (Fabaceae) is a medicinal legume characterized by its spines and pods, which are rich in saponins, polysaccharides, and various specialized metabolites with potential medicinal and industrial applications. The low fruit set rate in artificially cultivated economic forests significantly impedes its development and utilization.
View Article and Find Full Text PDFSeasonal hydrological variation impacts nitrogen speciation and enhances bioavailability in plateau lake sediments.
Water Res
December 2024
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China; National Observation and Research Station of Erhai Lake Ecosystem in Yunnan, Dali, 671000, PR China; Shanghai Jiao Tong University Yunnan Dali Research Institute, Dali, 671000, PR China. Electronic address:
Global warming has intensified the distinction between dry and wet seasons in monsoonal climates. The synergistic effect of high temperatures and rainfall during the wet season promotes the release of endogenous nitrogen (N) and eutrophication within lake ecosystems. However, the seasonal variations in sediments N speciation and bioavailability, and their intrinsic connection to release potential, remain unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!