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Surgery With Peripheral Nerve Block Under Dexmedetomidine Sedation for Foot Ulcer.
Plast Reconstr Surg Glob Open
November 2024
Department of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi-shi, Japan.
Article Synopsis
- Surgical treatment for diabetic foot ulcers (DFU) or chronic limb-threatening ischemia (CLTI) is complicated due to patients' poor health, making general anesthesia risky; therefore, peripheral nerve block with dexmedetomidine sedation is used in this study.
- The study involved 18 patients and assessed sedation levels, intraoperative stress, and memory using various scales, showing effective sedation and low stress levels during surgery, though some patients experienced hypoxemia.
- The findings indicate that using peripheral nerve block with dexmedetomidine can reduce patient stress and anxiety during surgery, but the potential for hypoxemia should be monitored closely.
Complex intestinal fistula treatment and care: A case report and literature review.
Medicine (Baltimore)
November 2024
Department of General Surgery, Jiaozhou Branch of Shanghai East Hospital, Tongji University, Qingdao, China.
Article Synopsis
- Abdominal cocoon is a rare condition that can lead to serious complications like intestinal rupture and fistulas, as seen in a 51-year-old man who experienced abdominal injuries from a traffic accident.
- The surgery revealed that his small intestine was encased in dense fibrous tissue, leading to complications that required intensive postoperative care, including ventilator support and drainage management.
- Despite the challenges of a delayed intestinal fistula occurring 10 days after surgery, comprehensive nursing strategies and treatments led to the successful healing of the incision, allowing the patient to eventually recover and reverse the stoma after 5 months.
Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate.
J Neuroinflammation
November 2024
Department of Molecular Biosciences, Davis, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Acute intoxication with cholinesterase inhibiting organophosphates (OP) can produce life-threatening cholinergic crisis and status epilepticus (SE). Survivors often develop long-term neurological consequences, including spontaneous recurrent seizures (SRS) and impaired cognition. Numerous studies implicate OP-induced neuroinflammation as a pathogenic mechanism contributing to these chronic sequelae; however, little is known about the inflammatory phenotype of innate immune cells in the brain following acute OP intoxication.
View Article and Find Full Text PDFFasudil Alleviates Postoperative Neurocognitive Disorders in Mice by Downregulating the Surface Expression of α5GABAAR in Hippocampus.
CNS Neurosci Ther
November 2024
Department of Anesthesiology, Key Laboratory of Cancer Prevention and Therapy, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Aim: Postoperative neurocognitive disorder (PND) refers to the cognitive impairment experienced by patients after surgery. As a target of sevoflurane, a kind of inhalation anesthetic, the balance of the GABAergic system can be disrupted during the perioperative period. In this study, we explored the promoting effect of abnormal elevation of the α5 subtype of γ-aminobutyric acid type A (GABAA) receptors caused by sevoflurane and surgical trauma on PND, as well as the therapeutic effect of fasudil on PND.
View Article and Find Full Text PDFDiagnostic ability and adverse events of mucosal incision-assisted biopsy for gastric subepithelial tumors: Systematic review and meta-analysis.
Dig Endosc
October 2024
Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Article Synopsis
- This study reviewed the effectiveness and safety of mucosal incision-assisted biopsy (MIAB) for diagnosing gastric subepithelial tumors (SETs).
- The analysis included 11 studies with a total of 339 cases, showing a high diagnostic rate of 87.8% and a very low adverse event rate of 0.2%.
- The use of acid secretion inhibitors proved effective in reducing postoperative bleeding, while the benefits of local injection to prevent complications were not clearly established.
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