Background: The use of the bilateral internal mammary arteries has been reserved mainly for younger and low risk patients.
Aim: To assess the safety and efficacy of BIMA grafting in older patients (> or = 70 years).
Methods: We reviewed the records of all consecutive patients > or = 70 years old who underwent coronary artery bypass surgery with a BIMA graft in our institute over a 2 year period. Demographic data, operative data, perioperative morbidity and mortality were recorded. Findings were compared with a matched-size group of patients who underwent CABG with a left internal mammary artery graft to left anterior descending artery.
Results: The study sample included 136 patients, of whom 68 underwent BIMA grafting and 68 LIMA grafting. Baseline demographic and clinical characteristics were similar in the two groups. There was no significant difference in operative mortality between the BIMA and LIMA groups (1.5% vs. 0%, P = 0.3) or in mortality during follow-up at a mean of 16 months (4.4% vs. 2.9%, P = 0.4, respectively). There was no difference between the groups in the incidence of perioperative complications, readmission and reintervention rates during follow-up. Significant between-group differences were noted for mean cardiopulmonary bypass time (93.2 +/- 34.7 min with BIMA vs. 108.8 +/- 40.7 min with LIMA, P = 0.02) and for red blood cell transfusion (1.9 +/- 1.9 vs. 4.3 +/- 2.8 packed cells/patient, P < 0.001).
Conclusions: The performance of mainly arterial revascularization with BIMA grafting in patients 70 years or older is as safe as LIMA grafting, with the added advantage of being a better conduit than saphenous vein graft, requiring fewer blood transfusions, and shorter cardiopulmonary bypass time.
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Cell Rep Med
December 2024
Department of Medical Oncology, National Taiwan University Cancer Center, Taipei City 106, Taiwan; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei City 100, Taiwan; Department of Oncology, National Taiwan University Hospital, Taipei City 100, Taiwan. Electronic address:
The efficacy of immunotherapy for estrogen receptor-positive/HER2-negative (ER+/HER2-) metastatic breast cancer (MBC) has not been proven. We conduct a phase 1b/2 trial to assess the efficacy of combining pembrolizumab (anti-PD1 antibody), exemestane (nonsteroidal aromatase inhibitor), and leuprolide (gonadotropin-releasing hormone agonist) for 15 patients with premenopausal ER+/HER2- MBC who had failed one to two lines of hormone therapy (HT) without chemotherapy. The primary endpoint of progression-free survival rate at 8 months (i.
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December 2024
Breast Center, São João University Hospital (ULS São João), 4200-319 Porto, Portugal.
(1) Background: Breast cancer (BC) has a high incidence in Europe, particularly in older adults. Traditionally under-represented in clinical trials, this age group is often undertreated due to ageism. This study aims to characterize frail older adults (≥70 years) with BC based on a comprehensive geriatric assessment, to guide individualized treatment decision-making.
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December 2024
Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G2M9, Canada.
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Internal Medicine, Waterbury Hospital, Waterbury, USA.
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December 2024
IRCCS San Raffaele Scientific Institute, Medical Physics Dept., Milan, Italy. Electronic address:
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