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Drug analysis in blowfly larvae and in human tissues: a comparative study.
Int J Legal Med
August 2004
Section of Legal Medicine, University of Bari Policlinico, Piazza Giulio Cesare, 70124, Bari, Italy.
The present study investigates the correlation between concentrations of drugs in human tissues and Diptera larvae feeding on these tissues. Samples of liver were taken from 18 cases in which preliminary toxicological screening indicated the presence of drugs. Blowfly larvae (Diptera: Calliphoridae) were reared on these samples and subsequently analyzed for drug content.
View Article and Find Full Text PDFNeonatal hair analysis for benzoylecgonine: a sensitive and semiquantitative biological marker for chronic gestational cocaine exposure.
Biol Neonate
January 2002
Medical University of South Carolina, 165 Ashley Avenue, PO Box 250917, Charleston, S.C. 29425, USA.
Hair analysis for the major metabolite of cocaine, benzoylecgonine (BZE) was performed in a cohort of 251 predominantly African-American newborns utilizing a modified radioimmunoassay (RIA) (Abuscreen Roche Laboratories, Nutley, N.J., USA).
View Article and Find Full Text PDFPrecision and comparability of Abuscreen OnLine assays for drugs of abuse screening in urine on Hitachi 917 with other immunochemical tests and with GC/MS.
Clin Lab
April 2000
Gemeinschaftspraxis für Laboratoriumsmedizin, Labor Dr. Kramer und Kollegen, Geesthacht, Germany.
Abuscreen OnLine assays for drugs of abuse screening in urine have recently been developed for use on Hitachi 917 analyzers (Roche Diagnostics GmbH). The assays are based on the kinetic interaction of microparticles as measured by changes in light transmission. Drug in a sample inhibits the formation of particle aggregates and diminishes absorbance change increases.
View Article and Find Full Text PDFDetermination of five abused drugs in nitrite-adulterated urine by immunoassays and gas chromatography-mass spectrometry.
J Anal Toxicol
October 1998
International Drug Monitoring Business Unit, Roche Diagnostic Systems, Inc., Somerville, New Jersey 08876, USA.
The adulteration of urine specimens with nitrite ion hasseen shown to mask the gas chromatography-mass spectrometry (GC-MS) confirmation testing of marijuana use. This study was designed to further investigate the effect of nitrite adulteration on the detection of five commonly abused drugs by immunoassay screening and GC-MS analysis. The drugs tested are cocaine metabolite (benzoylecgonine), morphine, 11-nor-delta-tetrahydrocannabinol-9-carboxylic acid (THCCOOH), amphetamine, and phencyclidine.
View Article and Find Full Text PDFA comparison of ONTRAK TESTCUP, abuscreen ONTRAK, abuscreen ONLINE, and GC/MS urinalysis test results.
J Forensic Sci
January 1998
Center for Human Toxicology, University of Utah, Salt Lake City, USA.
This study was designed to compare results obtained from two separate on-site drug testing kits (ONTRAK TESTCUP and Abuscreen ONTRAK) with those obtained from laboratory based immunoassay and GC/MS. Abuscreen ONLINE immunoassay was used to select 250 negative samples and 100 presumptive-positive samples each for cocaine/metabolites, opiates and cannabinoids. Presumptive-positive samples were selected if the immunoassay response was > or = 300 ng/mL for cocaine/metabolites (BZE), > or = 300 ng/mL for opiates or > or = 50 ng/mL for cannabinoids (THC-COOH).
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