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Stop-It Randomized Clinical Trial (RCT) for Intra-Abdominal Infection (IAI) Revisited: Multivariate Analyses To Identify Treatment Effects 4 Days Antibiotic Agents Versus Resolution Signs/Symptoms + 2 Days and Drivers of Outcomes.
Surg Infect (Larchmt)
December 2024
Department of Surgery, Inspira Health Network, Vineland, New Jersey, USA.
: The STOP-IT randomized clinical trial (RCT) pioneered limiting antibiotic agents in intra-abdominal infection (IAI) with adequate surgical source control, but NIH funding ended before an adequate power sample size was enrolled to determine equivalence between STOP-IT study regimens: four days of antibiotic agents (4-days) after source control versus antibiotic agents until resolution of signs and symptoms of IAI plus two days (standard of care [SOC]). The objective of this investigation was to identify possible significant treatment effects 4-days versus SOC, and independent variables defining and predicting outcomes. : De-identified data from 518 STOP-IT subjects were analyzed retrospectively in two groups: 4-days (n = 258) and SOC (n = 260), and separately as one group (n = 518).
View Article and Find Full Text PDFEffects of the Interaction of Salinity and Rare Earth Elements on the Health of : The Case of Praseodymium and Europium.
J Xenobiot
December 2024
Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.
The growing use of products containing rare earth elements (REEs) may lead to higher environmental emissions of these elements, which can potentially enter aquatic systems. Praseodymium (Pr) and europium (Eu) are widely used REEs with various applications. However, their ecotoxicological impacts remain largely unexplored, with poorly understood risks to wildlife.
View Article and Find Full Text PDFPotential Impact of Microbial Variations After Peri-Implantitis Treatment on Peri-Implant Clinical, Radiographic, and Crevicular Parameters: A Systematic Review.
Dent J (Basel)
December 2024
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Salerno, Italy.
This systematic review evaluated concomitant trends in microbial (total biofilm load and pre-dominant pathogens' counts) and clinical, radiographic, and crevicular variations following (any) peri-implantitis treatment in partially vs. totally edentulous, systemically healthy, non-smoking adults and compared them to peri-implant mucositis treated sites. The study protocol, compliant with the PRISMA statement, was registered on PROSPERO (CRD42024514521).
View Article and Find Full Text PDFBehind the scenes with genomics researchers.
Front Genet
December 2024
Department of Economics, Faculty of Social Sciences, Brock University, St. Catharines, ON, Canada.
Although lab-coat genomics scientists are highly skilled and involved in pioneering work, few studies have examined their perceptions on what they do, and how they relate with others in interdisciplinary work. Recognizing that gap, we were curious to talk with scientists about their current work and positionalities related to the use of genomics for bioremediation. Using unstructured open-ended interviews and thematic analysis, we interviewed researchers with diverse genomics-related expertise.
View Article and Find Full Text PDFThe use of the differential outcomes procedure for the recognition of facial expressions of complex emotions and its electrophysiological correlates.
Front Psychol
December 2024
Department of Psychology, University of Almería, Almería, Spain.
The differential outcomes procedure (DOP) is an easily applicable method for enhancing discriminative learning and recognition memory. Its effectiveness in improving the recognition of facial expressions of emotion has been recently explored, with mixed success. This study aims to explore whether the expectancies generated via the DOP are reflected as differences in event-related potentials (ERPs) between participants in differential (DOP) or non-differential conditions (NOP) in a facial expression of complex emotion label task.
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