The two major challenges in the diagnostic procedure of sarcoidosis are the differential diagnosis and the determination of the extent of the disease. 1) The corner stone of differential diagnosis is the histological demonstration of non-caseating granulomas. Obtaining an appropriate sample for histological examination often requires invasive examinations. A minimal invasive sampling method, the labial biopsy, not yet practiced in Hungary is showed in the first part of this paper. 2) Cardiac involvement has great importance in the evaluation of the extent of the disease. MRI is the most accurate method available to date to demonstrate cardiac sarcoidosis. The first MRI proven cardiac sarcoidosis in the Hungarian medical literature is reported in the second part of the article.
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