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Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period. | LitMetric

Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period.

Biosci Biotechnol Biochem

Graduate School of Nutritional and Environmental Sciences, COE Program for the Twenty-First Century, University of Shizuoka, Shizuoka, Japan.

Published: May 2007

AI Article Synopsis

  • Jejunal GLUT5 levels increase in rats during weaning when treated with triiodothyronine (T(3)).
  • When fructose is perfused into the small intestine of T(3)-injected rats, it stimulates the expression of the GLUT5 gene, while it does not have the same effect in vehicle-injected rats.
  • The findings indicate that T(3) and fructose work together to upregulate GLUT5 gene expression in the jejunum of rats during the weaning phase.

Article Abstract

Jejunal GLUT5 is elevated with triiodothyronine (T(3)) during weaning of rats. A perfusion of fructose into the small intestine of T(3)-injected rats at 21 d induced expression of the GLUT5 gene, but one into that of vehicle-injected rats did not. These results suggest that T(3) and fructose coordinately enhance jejunal expression of the GLUT5 gene in rats during weaning period.

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Source
http://dx.doi.org/10.1271/bbb.70014DOI Listing

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