MicroRNAs (miRNAs) are a class of small regulatory RNAs, which repress gene expression at the posttranscriptional levels through binding to target mRNAs for directly cleaving mRNAs or inhibiting protein translation. Mature miRNAs are produced from miRNA genes by multiple biological processes, in which several important enzymes are involved in. To date, several hundreds of miRNAs have been identified in plants using a various computational and/or experimental approaches. These miRNAs regulate plant tissue differentiation, development and growth, control auxin signal transduction, involve in plant response to a variety of abiotic and biotic environmental stresses.
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Cancer Rep (Hoboken)
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Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
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A noninvasive urinary microRNA-based assay for the detection of pancreatic cancer from early to late stages: a case control study.
EClinicalMedicine
December 2024
Department of Pathology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido, Japan.
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Leeds Institute of Medical Research, School of Medicine, University of Leeds, St. James University Hospital, Leeds, United Kingdom.
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View Article and Find Full Text PDFRegulatory networks of mRNAs and miRNAs involved in the immune response of diamondback moth, Plutella xylostella to fungal infection.
BMC Genomics
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Institute of Plant Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
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View Article and Find Full Text PDFRegulation of innate immune response by miRNAs up-regulated in Stevens-Johnson syndrome with severe ocular complications.
Sci Rep
January 2025
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Hirokoji, Kawaramachi, Kamigyoku, Kyoto, 602-0841, Japan.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous disorders characterized by extensive tissue necrosis; they are often accompanied by severe ocular complications (SOC). The regulatory role of microRNAs (miRNAs) in modulating immune responses in SJS/TEN is not fully understood, particularly in relation to chronic SOC. We explored the expression profiles of specific miRNAs and their potential impact on the regulation of key innate immune genes in patients with SJS/TEN with SOC.
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