The enteric glial cells, in addition to being support structures for the enteric nervous system, have many other additional roles, such as modulators for the homeostasis of enteric neurons, cells involved in enteric neurotransmission and antigen-presenting cells. Moreover, in the last years, data have been accumulating that demonstrate a possible active role of these cells in the pathophysiology of gastrointestinal motor activity. Thus, as also shown by recent evidence in both experimental animal models, and in some human diseases, alterations of enteric glial cells might have some role in the development of intestinal motor abnormalities.
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Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease.
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Article Synopsis
- Cancer treatments can lead to severe gastrointestinal side effects, both acute (short-term) and chronic (long-term), impacting patients' overall health.
- This article reviews chemotherapy's neurotoxic effects on the enteric nervous system (ENS) and how chemotherapy-induced enteric neuropathy (CIEN) may cause persistent gastrointestinal dysfunctions.
- Research indicates that CIEN results in reduced nerve cell density and altered neuronal activity in the ENS, affecting gut functions and potentially leading to brain-gut axis disorders, highlighting the need for more research in this overlooked area.
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