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Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity.
Histopathology
November 2024
Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.
Aims: Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal mucoepidermoid carcinoma (MEC), another uncommon tumour in this region. ASC is believed to originate from metaplastic squamous epithelium, though it may also arise from respiratory epithelium in respiratory epithelial adenomatoid hamartoma (REAH) or seromucinous glands in seromucinous hamartoma (SH).
View Article and Find Full Text PDFAdenomatoid Tumor Mimicking Peritoneal Carcinomatosis: A Case Report.
Int J Gynecol Pathol
October 2024
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
An adenomatoid tumor (AT) is a benign lesion, which is commonly located in the genital tract of both sexes. We present a case of a 66-yr-old woman with the unusual characteristics of an AT mimicking peritoneal carcinomatosis. The tumor was detected incidentally by ultrasound examination, and an ensuing imaging study raised suspicion of ovarian cancer with peritoneal carcinomatosis.
View Article and Find Full Text PDFA Rare Case of Giant Cystic Adenomatoid Tumor of the Uterus With Literature Review.
Case Rep Obstet Gynecol
October 2024
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Adenomatoid tumors are rare benign neoplasms arising from mesothelial cells, commonly found in the female genital system, particularly the uterus and fallopian tubes. The giant cystic variant of adenomatoid tumor is exceptionally rare and can cause massive growth mimicking malignant gynecological conditions. Histology and immunohistochemistry play a crucial role in confirming the diagnosis, with markers such as calretinin, D2-40, CK7, BAP1, ER, and WT1 proving useful.
View Article and Find Full Text PDFGenomic instability in congenital lung malformations in children.
Pediatr Surg Int
September 2024
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Article Synopsis
- - The study investigates the link between congenital lung malformations (CLMs) and the risk of developing cancer by examining genetic mutations in various lung malformations through whole-genome sequencing.
- - Analysis revealed that 95% of the CLMs exhibited genomic instability, with 30% harboring genetic variants associated with tumor development, suggesting a potential predisposition to malignancy.
- - The findings indicate that while CLMs are often benign, their genetic alterations, combined with environmental carcinogenic factors, may increase the likelihood of lung cancer, highlighting a significant biological connection.
Single-stage Open Lobectomy and Modified Ravitch Procedure in an Infant with Coexisting Severe Pectus Excavatum and Congenital Cystic Adenomatous Malformation.
Afr J Paediatr Surg
July 2024
Department of Surgery, Cardiothoracic Surgery Unit, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Coexisting congenital cystic adenomatous malformation of the lungs and severe pectus excavatum (PE) is an uncommon presentation that poses significant management challenges. Conventionally managed in a staged manner, there are increasing reports of superior outcomes with single-staged concurrent repair with minimally invasive techniques (video-assisted thoracoscopic surgery [VATS] and minimally invasive repair of PE [MIRPE]). The outcome of a single-stage open repair for both anomalies has not been previously reported to the best of our search.
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