ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

Bioorg Med Chem Lett

Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.

Published: July 2007

A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta.

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http://dx.doi.org/10.1016/j.bmcl.2007.04.068DOI Listing

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