AI Article Synopsis
- The study evaluated how primary coronary angioplasty (PCA) affects heart function and shape after a heart attack in 99 patients.
- PCA helped improve regional heart muscle function, particularly in saving the injured areas of the heart.
- Despite improvements in contractility, the overall shape of the heart remained abnormal in many patients over time.
Article Abstract
Objectives: To evaluate the effects of primary coronary angioplasty (PCA) on regional left ventricular (LV) contractile dysfunction and deformation, and on global remodeling.
Methods: In 99 consecutive patients (81 males, aged 61+/-11 years) who underwent successful PCA of left anterior descending (LAD) and right coronary (RCA) arteries for treatment of first myocardial infarction and completed a hemodynamic follow-up at 1 and 6 months, LV eccentricity and circularity indexes, centreline wall motion and regional curvature were analyzed. Asynergy and akinesia were defined as centreline impairment -1 standard deviation) at 6 months was used to categorize the outcome as improved.
Results: Systolic deformation and impairment of regional LV function soon after LAD and RCA occlusion closely resembled those of the chronic myocardial infarction. PCA improved regional contractility in all patients, due to early salvage of the epicardial injured myocardium, and at least in two fifths of patients the injury area magnitude reduced by improvement of the ischemic boundaries of the infarct. Irrespective of either persistently impaired or normalized regional contractility, LV shape remained abnormal. In contract to the persistence of local deformation, global remodeling was observed in patients categorized as the highest end-diastolic volume quartile at presentation who had greater myocardial damage.
Conclusion: Regional contractility impairment induced by acute myocardial infarction can be reverted by PCA, but systolic shape deformation persists over time.
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| http://dx.doi.org/10.1016/j.ijcard.2007.03.113 | DOI Listing |
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