Epidemiologic studies have revealed that the protective association of high-density lipoprotein cholesterol (HDL-C) with CHD is stronger in older men and younger women. We aimed to investigate sex differences in the relation of HDL-C to progression of carotid intima-media thickness (IMT) (an indicator of subclinical atherosclerosis) in middle age. IMT progression and serum HDL-C were determined for a cohort of 500 women and men aged 40-60 years over three examinations (1.5-year intervals). IMT at baseline was inversely associated with serum levels of HDL-C and the associations were comparable in women and men. However, in multivariate longitudinal growth models adjusting for potential confounders, IMT progression was inversely associated with serum levels of HDL-C in men, but directly associated in women (p=0.0007 for interaction). Our results suggest that although HDL-C was protective against progression of carotid atherosclerosis in middle-aged men, anti-atherogenic effects of HDL may diminish in women around the age of menopause.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.atherosclerosis.2007.03.045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers and Social Determinants in atherosclerotic Arterial Diseases: A Scoping Review.
Ann Vasc Surg
January 2025
Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy; Interuniversity Center of Phlebolymphology (CIFL), "Magna Graecia" University, 88100 Catanzaro, Italy. Electronic address:
Background: Arterial diseases like coronary artery disease, carotid stenosis, peripheral artery disease, and abdominal aortic aneurysm have high morbidity and mortality, making them key research areas. Their multifactorial nature complicates patient treatment and prevention. Biomarkers offer insights into the biochemical and molecular processes, while social factors also significantly impact patients' health and quality of life.
View Article and Find Full Text PDFLipidomic Expression Analysis In Carotid Atherosclerotic Disease: A Systematic Review.
Ann Vasc Surg
January 2025
Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL. Electronic address:
Objective: Lipids are key molecules for atherosclerosis, with tight regulation mechanisms, making them potential biomarkers for disease-specific diagnostics and therapeutics. Therefore, we aim to perform a systematic literature review on lipidomic analysis in serum/plasma and plaque samples of patients with carotid atherosclerosis.
Methods: We performed a systematic review following the PRISMA guidelines on the lipidomic profile in serum/plasma and carotid artery plaques from patients with significant carotid disease by degree of stenosis in preoperative imaging and clinical presentation (symptomatic, asymptomatic, radiation-induced carotid disease).
Carotid-Femoral Pulse Wave Velocity in Children in South Africa: Reference Values for the Vicorder Device.
Angiology
January 2025
Family Center for Research with Ubuntu, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.
Atherosclerosis often starts in childhood, tracking to adulthood. In children, early vascular disease can be detected as arterial stiffness. Carotid-femoral pulse wave velocity is considered the non-invasive gold standard method for measuring arterial stiffness and widely accepted for use in children.
View Article and Find Full Text PDFTechnical note: Enhanced radiosurgical planning for cavernous sinus tumors using T1 SPACE sequences with Motion-Sensitized Driven Equilibrium (MSDE).
J Clin Neurosci
January 2025
Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Electronic address:
Background And Objective: Radiosurgery can serve as a primary, adjuvant, or salvage treatment modality for cavernous sinus tumors (CST), providing high tumor control. However, particularly with cavernous sinus expansion, there may be insufficient distance from the optic apparatus to perform radiosurgery safely. The internal carotid artery adjacent to the distal dural ring (ICAddr), when enhancing similarly to the CST, can be difficult to delineate, and can lead to over-contouring of target volume near the optic nerve and therefore increasing the risk of radiation-induced optic toxicity.
View Article and Find Full Text PDFSex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.
Front Aging Neurosci
January 2025
Department of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
Introduction: Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit () mouse allows investigation of early biomarkers and mechanisms of brain injury.
Methods: Using high-frequency ultrasound, the common carotid arteries of female and male and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) ( = 6 mice/group/sex).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!