Objectives: To independently evaluate phase-shift treatment for predominant tone tinnitus.

Study Design: Prospective, single-blinded crossover study.

Methods: 61 subjects with predominant tone tinnitus participated in 2 weeks of control and 2 weeks of phase-shift treatment. Frequency and intensity matching, pre- and post-treatment tinnitus handicap inventory (THI) scores, and patient diaries were outcome measures.

Results: Initial volume comparisons show a strong relationship between treatment and decrease in tinnitus intensity, with 57% of patients achieving successful treatment. Thirty-seven percent decreased by one THI grade, 5% by two. Utilizing patient diaries, 42% of patients reported periods of complete residual inhibition (CRI) ranging from 1 hour to 7 days (average 2 days). No periods of CRI were reported in control weeks.

Conclusion: Phase-shift treatment significantly benefited the majority of our patients. These outcomes suggest that this device may be a valuable tool. Further long-term studies with home therapy are warranted.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otohns.2006.10.046DOI Listing

Publication Analysis

Top Keywords

phase-shift treatment
16
predominant tone
12
treatment predominant
8
tone tinnitus
8
patient diaries
8
treatment
5
phase-shift
4
tinnitus
4
tinnitus objectives
4
objectives independently
4

Similar Publications

The dynamic behavior of articular cartilage (a soft porous biological tissue) with strain-dependent nonlinear permeability under cyclic compressive loading and magnetic field is investigated computationally. The compressive force is applied on top surface of the cylindrical plug of the tissue by means of a porous filter. The study of mechanical and deformational behavior of soft porous tissues such as articular cartilage under dynamic compressive loading and magnetic field is useful in understanding the underlying mechano-biological process that may lead to the development of a treatment and recovery protocol in a diseased state.

View Article and Find Full Text PDF

Melanoma, which originates from pigment-producing melanocytes, is an aggressive and deadly skin cancer. Despite extensive research, its mechanisms of progression and metastasis remain unclear. This study uses quantitative phase imaging via digital holographic microscopy, Principal Component Analysis (PCA), and t-distributed Stochastic Neighbor Embedding (t-SNE) to identify the morphological, optical, and behavioral differences between normal melanocytes and SK-MEL-28 melanoma cells.

View Article and Find Full Text PDF

Perfluorocarbon (PFC) droplets represent a novel class of phase-shift contrast agent with promise in applications in biomedical and bioengineering fields. PFC droplets undergo a fast liquid-gas transition upon exposure to acoustic or optical triggering, offering a potential adaptable and versatile tool as contrast agent in diagnostic imaging and localized drug delivery vehicles in therapeutics systems. In this paper, we utilize advanced imaging techniques to investigate ultra-high-speed inertial dynamics and rectified quasi-static (low-speed) diffusion evolution of optically induced PFC droplet vaporization within three different hydrogels, each of different concentrations, examining effects such as droplet size and PFC core on bubble dynamics and material viscoelastic properties.

View Article and Find Full Text PDF

Exenatide administration time-dependently affects the hepatic circadian clock through glucagon-like peptide-1 receptors in the central nervous system.

Biochem Pharmacol

December 2024

Department of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. Electronic address:

Accumulating evidence indicates that disruption of the circadian clock contributes to the development of lifestyle-related diseases. We have previously shown that exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, can strongly affect the molecular clocks in the peripheral tissues. This study aimed to investigate the effects of its dosing time and the central nervous system-specific GLP-1 receptor knockdown (GLP1RKD) on the hepatic clock in mice treated with exenatide.

View Article and Find Full Text PDF

Articular cartilage fatigue causes frequency-dependent softening and crack extension.

J Mech Behav Biomed Mater

December 2024

Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Article Synopsis
  • Soft biological polymers like articular cartilage are highly resistant to fractures and fatigue, making them key models for new material development, yet we need to better understand their behavior under stress.
  • The study examined cartilage's mechanical properties under different frequencies and cycles of cyclic compression, measuring thickness, stiffness, and crack growth.
  • Results showed that repetitive loading led to irreversible damage and changes in material behavior, with higher frequencies resulting in less deterioration, which can enhance our knowledge of cartilage failure and aid osteoarthritis treatment.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!