This paper presents a new framework for shape modeling and analysis, rooted in the pattern recognition theory and based on artificial neural networks. Growing and adaptive meshes (GAMEs) are introduced: GAMEs combine the self-organizing networks which grow when require (SONGWR) algorithm and the Kohonen's self-organizing maps (SOMs) in order to build a mesh representation of a given shape and adapt it to instances of similar shapes. The modeling of a surface is seen as an unsupervised clustering problem, and tackled by using SONGWR (topology-learning phase). The point correspondence between point distribution models is granted by adapting the original model to other instances: the adaptation is seen as a classification task and performed accordingly to SOMs (topology-preserving phase). We thoroughly evaluated our method on challenging synthetic datasets, with different levels of noise and shape variations. Finally, we describe its application to the analysis of a challenging medical dataset. Our method proved to be reproducible, robust to noise, and capable of capturing real variations within and between groups of shapes.
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http://dx.doi.org/10.1016/j.media.2007.03.006 | DOI Listing |
Langmuir
January 2025
Dipartimento di Fisica e Chimica - Emilio Segré, Università degli Studi di Palermo, Viale delle Scienze ed. 18, 90128 Palermo, Italy.
Amyloid fibrils have recently emerged as promising building blocks for functional materials due to their exceptional physicochemical stability and adaptable properties. These protein-based structures can be functionalized to create hybrid materials with a diverse range of applications. Here we report a simple eco-friendly protocol for generating amyloid fibrils from hen egg white lysozyme decorated with gold nanoparticles that can self-assemble in a hydrogel.
View Article and Find Full Text PDFPhysiol Plant
January 2025
Zhengzhou Research Base, State Key Laboratory of Cotton Bio-breeding and Integrated Utilization, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, China.
Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) are a class of highly conserved serine/threonine-protein kinases in eukaryotes. They participate in the typical MAPK cascade system and various signal transduction pathways regulating biological processes in plants, during stressful conditions. To date, genome-wide identification of MAP4Ks in cotton has not been reported.
View Article and Find Full Text PDFInt J Antimicrob Agents
December 2024
University of Amsterdam, Swammerdam Institute of Life Sciences, Molecular Biology and Microbial Food Safety, Amsterdam, The Netherlands. Electronic address:
Antibiotic resistance is a growing global healthcare challenge, treatment of bacterial infections with fluoroquinolones being no exception. These antibiotics can induce genetic instability through several mechanisms, one of the most significant being the activation of the SOS response. During exposure to sublethal concentration, this stress response increases mutation rates, accelerating resistance evolution.
View Article and Find Full Text PDFSoc Sci Med
December 2024
ESHPM, Erasmus University Rotterdam, the Netherlands.
Capacity problems in healthcare lead organizations to seek new and fluid ways of organizing care to safeguard access to services. Task reallocation, triage and stepped care models are increasingly foregrounded as promising interventions that enhance the capacity, efficiency, and resilience of medical services and through which access can be maintained for a growing client base. In this paper, we argue that interventions meant to enhance capacity and increase efficiency have their limits in a system that is already under strain.
View Article and Find Full Text PDFJMIR Res Protoc
December 2024
Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada.
Background: Sedentary lifestyles, poor nutritional choices, inadequate sleep, risky substance use, limited social connections, and high stress contribute to the growing prevalence of chronic diseases. Lifestyle medicine, emphasizing therapeutic lifestyle changes for prevention and treatment, has demonstrated effectiveness but remains underutilized in clinical settings. The Complete Lifestyle Medicine Intervention Program-Ontario (CLIP-ON) was developed to educate the rural population of Northern Ontario in lifestyle medicine to improve health outcomes and engagement.
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