This article outlines the issues that influence the process of writing a 'do not attempt resuscitation' order. It discusses advance directives, the Mental Capacity Bill and patient and relative involvement, and their impact on making decisions about cardiopulmonary resuscitation (CPR).
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Joint action partners modulate the first step of an action sequence to communicate a distal goal.
Acta Psychol (Amst)
January 2025
Department of Linguistics, Cognitive Science, and Semiotics, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark; Interacting Minds Centre, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark. Electronic address:
When two co-actors perform a joint action, they often communicatively modulate their instrumental actions so as to facilitate each other's predictions of their immediate, proximal goals. Here, we ask whether co-actors would also engage in such "sensorimotor communication" for distal goals, specifically those that result from a two-step action sequence. To address this question, we asked pairs of participants to work together to deliver an animated box to one of two delivery locations displayed on a computer screen.
View Article and Find Full Text PDFProtein binding and folding through an evolutionary lens.
Curr Opin Struct Biol
January 2025
Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden. Electronic address:
Protein-protein associations are often mediated by an intrinsically disordered protein region interacting with a folded domain in a coupled binding and folding reaction. Classic physical organic chemistry approaches together with structural biology have shed light on mechanistic aspects of such reactions. Further insight into general principles may be obtained by interpreting the results through an evolutionary lens.
View Article and Find Full Text PDFCharacterization of Cutaneous Radiation Syndrome in a Mouse Model Using [18F]F- Fluorodeoxyglucose Positron Emission Tomography.
Health Phys
January 2025
Nuclear Medicine and Molecular Imaging Sciences Program, Department of Clinical & Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL.
Ionizing radiation on the skin has the potential to cause various sequelae affecting quality of life and even leading to death due to multi-system failure. The development of radiation dermatitis is attributed to oxidative damage to the skin's basal layer and alterations in immune response, leading to inflammation. Past studies have shown that [18F]F-2-fluoro-2-deoxyglucose positron emission tomography-computed tomography ([18F]F-FDG PET/CT) can be used effectively for the detection of inflammatory activity, especially in conditions like hidradenitis suppurativa, psoriasis, and early atherosclerosis.
View Article and Find Full Text PDFVaginal delivery of the second twin: simulation to improve trainee knowledge and comfort.
Minerva Obstet Gynecol
January 2025
Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: Vaginal delivery in twins is feasible but challenging. Successful vaginal delivery of a non-vertex second twin depends on knowledge of specific obstetrical maneuvers. Skill acquisition at the patient's bedside is difficult, making simulation training an integral part of obstetrics and gynecology residency programs.
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