An estimation and assessment of the polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo furans (PCDD/Fs) exposure levels for the people living in Kocaeli, the most industrialized area of Turkey, are presented. The information is based on the results of PCDD/F analyses in the samples collected from various environmental media and the multimedia exposure assessment methodology. Exposure scenarios were constructed on a site-specific basis by combining the exposure pathways appropriate to the area, and the activity patterns of the people living in Kocaeli. The model showed that the exposure levels of PCDD/Fs were in the range of 3.7-13.1 pg I-TEQ.kg-1 bw for adult receptors, which are higher than the recommended TDI value of 2 pg TEQ.kg-1 bw. The PCDD/F intakes for rural receptors were estimated to be three times higher than those for urban and semi-urban receptors due mainly to the consumption of locally grown foods. The assessment of the contributions of various exposure pathways to the total exposure and the sensitivity analysis performed based on a probabilistic approach indicated that PCDD/F intakes for adult receptors are directly proportional to the locally grown fraction of plant groups consumed.
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http://dx.doi.org/10.1080/10934520701304393 | DOI Listing |
Sci Adv
January 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
The transmission bottleneck, defined as the number of viruses shed from one host to infect another, is an important determinant of the rate of virus evolution and the level of immunity required to protect against virus transmission. Despite its importance, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission bottleneck remains poorly characterized. We adapted a SARS-CoV-2 reverse genetics system to generate a pool of >200 isogenic SARS-CoV-2 viruses harboring specific 6-nucleotide barcodes, infected donor hamsters with this pool, and exposed contact hamsters to paired infected donors, varying the duration and route of exposure.
View Article and Find Full Text PDFJ Acquir Immune Defic Syndr
November 2024
University of Washington, Seattle, WA, United States.
Introduction: Adolescent girls and young women (AGYW) in Kenya have low pre-exposure prophylaxis (PrEP) initiation rates in part due to stigmatizing interactions with health care providers. Our recent randomized clinical trial of a standardized patient actor (SP) training intervention for providers found higher quality PrEP delivery at intervention sites, however it was unclear whether improved service quality improved PrEP initiation.
Methods: This analysis used routine records from facilities participating in the randomized trial which aimed to improve provider communication and adherence to Kenyan guidelines when offering PrEP to AGYW.
PLOS Glob Public Health
January 2025
Aix Marseille Univ, IRD, INSERM, SESSTIM, ISSPAM, Marseille, France.
Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine is recommended by the World Health Organization since 2012 for clinical malaria prevention in children in the Sahelian region of Africa. In Senegal, SMC implementation began in 2013 and is given to children under 10 years old. This study aimed to describe clinical malaria incidence in the general population during routine SMC implementation and to analyse how SMC timing impacted clinical malaria dynamics in eligible children.
View Article and Find Full Text PDFPLoS One
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrates (TAILS) to identify cleaved host substrates.
View Article and Find Full Text PDFEur J Prev Cardiol
January 2025
Department of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Aim: Air pollution remains the single largest environmental health risk factor, while atrial fibrillation (AF) is the most prevalent arrhythmia globally. The study aimed to investigate the relationship between short-term exposure to air pollution and acute AF admissions.
Methods: Individual data on AF hospitalization in the years 2011-2020 were collected from the National Health Fund in Poland (ICD-10: I48.
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