AI Article Synopsis
- (67)Ga binds to transferrin and is transported to tissues; this study investigates its uptake in the liver after partial hepatectomy (PH) compared to blood loss from venesection.
- In rats, both PH and venesection resulted in decreased blood cells and transferrin levels, but the effects on (67)Ga uptake differed between the two methods.
- After PH, the liver showed a significant increase in (67)Ga uptake, while reticulocytes (immature red blood cells) did not; the opposite occurred after venesection, highlighting the role of transferrin receptors in these processes.
Article Abstract
As (67)Ga is injected into the blood, (67)Ga is immediately bound to transferrin (Tf) and transported to various tissues and the Tf-(67)Ga complex binds to Tf receptor on various tissues. In partial hepatectomy (PH) a part of blood in circulation is lost together with removed liver tissues, consequently the amounts of blood cells and Tf in circulation decrease. In order to investigate the effect of those decreases on (67)Ga uptake by the liver, we compared the uptake in partially hepatectomized rats with that in venesectioned rats in which only a part of blood in circulation decreased. A two-thirds PH was performed. Two milliliters of blood was venesectioned. Each treated rat was intraveneously injected with (67)Ga. The changes of erythrocyte and reticulocyte contents after PH did not differ from those after venesection (VS) at all. But (67)Ga uptake by reticulocytes significantly increased after VS but did not after PH. On the other hand, (67)Ga uptake by the liver significantly increased after PH but did not after VS. These differences must be related to the different expression of Tf receptors on the liver after PH and VS.
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| http://dx.doi.org/10.1248/bpb.30.1011 | DOI Listing |
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