Nectin is an immunoglobulin-like cell-cell adhesion molecule, which plays essential roles in the initial step of formation of adherens junctions and tight junctions. We demonstrate here the role of nectin-1 in the epidermis using nectin-1-/- mice. Newborn nectin-1-/- pups showed shiny and slightly reddish skin; the amount of loricrin, one of the differentiation markers and also a major component of cornified cell envelopes, was markedly reduced in the epidermis of nectin-1-/- mice. The amounts of repetin and SPRRP, other components of cornified cell envelopes, were markedly elevated probably due to a compensatory mechanism to overcome the impaired expression of loricrin. However, cornified cells from nectin-1-/- mice were sensitive to mechanical stress. Moreover, Ca2+-induced activation of ERK through Rap1 and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes; in turn, the inhibition of ERK activation reduced the amount of loricrin in wild-type keratinocytes. These results indicate that nectin-1 plays a key role in the expression of loricrin in the epidermis.
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- Early-life stress (ES) negatively affects cognitive abilities in female adolescents, with research indicating that specific cell adhesion molecules, NECTIN1 and NECTIN3, might play a role in this dysfunction.
- In a study using a model of limited bedding, it was found that ES impaired recognition memory and altered the expression of NECTIN1 and NECTIN3, alongside increases in corticotropin-releasing hormone (Crh).
- The findings suggest that reduced NECTIN3 in the dorsal CA1 area of the hippocampus is linked to memory impairments due to stress, while targeting CRHR1 can enhance NECTIN3 levels and improve memory functions.
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