Toxoplasma gondii is an obligate intracellular parasite occurring in both animals and humans throughout the world. Infection with Toxoplasma gondii can lead to congenital and acquired disease. Different techniques for the diagnosis of this disease have been used. The aim of this study was to determine the prevalence of IgG and IgM antibody to Toxoplasma gondii in patients. This study was carried out between 1999 and 2003; antibody titers were detected by ELISA in the sera of 4908 patients. The results showed that 1522 (31.01%) patients were IgG positive, and 38 (0.77%) patients were IgM positive with the ELISA test. Besides this, T. gondii specific IgG antibody was found in 171 (31.09%) newborn patients.
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Nat Commun
January 2025
Laboratory of Pathogens and Host Immunity, UMR 5294 CNRS, UA15 INSERM, Université de Montpellier, Montpellier, 34095, France.
Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death and the effectors involved remain poorly characterized. We identified ROP55, a rhoptry protein that promotes parasite survival by preventing lytic cell death in absence of IFN-γ stimulation.
View Article and Find Full Text PDFVet Parasitol
January 2025
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China; Chongqing Academy of Animal Sciences, Chongqing, PR China. Electronic address:
Toxoplasmosis is an important public health concern. Cats play a crucial role in increasing the risk of toxoplasmosis transmission to humans. Early diagnosis in cats is essential for the prevention and control of toxoplasmosis.
View Article and Find Full Text PDFRev Bras Parasitol Vet
January 2025
Hospital Veterinário Jerônimo Dix-Huit Rosado Maia, Universidade Federal Rural do Semi-Árido - UFERSA, Mossoró, RN, Brasil.
This study investigated infection by Leishmania spp., Leptospira spp., Toxoplasma gondii, and Trypanosoma cruzi in six-banded armadillos (Euphractus sexcinctus) from the semiarid region of northeastern Brazil.
View Article and Find Full Text PDFRetina
January 2025
L V Prasad Eye Institute, GMR Varalaxmi Campus, Visakhapatnam, Andhra Pradesh, India.
Purpose: To study the role of intravitreal clindamycin with dexamethasone as an adjuvant to systemic co-trimoxazole and steroids in macular Toxoplasma retinochoroiditis.
Methods: Retrospective study of Toxoplasma retinochoroiditis cases from January 2014 to December 2021 treated with a combination of oral and intravitreal therapy in immunocompetent patients.
Results: 39 eyes of 39 patients were included in this study after meeting the inclusion criteria with the mean age of presentation being 25.
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