Purpose: The aim of this work was to determine the effect of sodium fluoride at a dose of 4.9 mg/kg b.w./24 h and caffeine at a dose of 3 mg/kg b.w./24 h on the concentration of fluoride in serum and its content in teeth and bones of rats.
Material And Methods: The study was done in 18 male Sprague-Dawley rats.
Conclusions: A negative effect of caffeine administered concurrently with sodium fluoride on teeth and bones of rats was demonstrated as reflected by a tendency to increased content of fluoride in bones and decreased content in teeth.
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