[The effect of caffeine and sodium fluoride on fluoride concentration in serum and its content in teeth and bones of rats].

Ann Acad Med Stetin

Zakład Biochemii Ogólnej, Katedra Biochemii Slqskiej Akademii Medycznej w Katowicach ul. Jordana 19, 41-808 Zabrze.

Published: June 2007

Purpose: The aim of this work was to determine the effect of sodium fluoride at a dose of 4.9 mg/kg b.w./24 h and caffeine at a dose of 3 mg/kg b.w./24 h on the concentration of fluoride in serum and its content in teeth and bones of rats.

Material And Methods: The study was done in 18 male Sprague-Dawley rats.

Conclusions: A negative effect of caffeine administered concurrently with sodium fluoride on teeth and bones of rats was demonstrated as reflected by a tendency to increased content of fluoride in bones and decreased content in teeth.

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