Brassinin is a phytoalexin produced by plants from the family Brassicaceae that displays antifungal activity against a number of pathogens of Brassica species, including Leptosphaeria maculans (Desm.) Ces. et de Not. [asexual stage Phoma lingam (Tode ex Fr.) Desm.] and L. biglobosa. The interaction of a group of isolates of L. maculans virulent on brown mustard (Brassica juncea) with brassinin was investigated. The metabolic pathway for degradation of brassinin, the substrate selectivity of the putative detoxifying hydrolase, as well as the antifungal activity of metabolites and analogs of brassinin are reported. Brassinin hydrolase activity was detectable only in cell-free homogenates resulting from cultures induced with brassinin, N'-methylbrassinin, or camalexin. The phytoalexin camalexin was a substantially stronger inhibitor of these isolates than brassinin, causing complete growth inhibition at 0.5mM.
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Indole phytochemical camalexin as a promising scaffold for AcrB efflux pump inhibitors against Escherichia coli.
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Laboratory of Food Chemistry, Wageningen University and Research, Bornse Weilanden, Wageningen 6708 PD, the Netherlands. Electronic address:
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Indole phytoalexins, found in economically significant family plants, are synthesized in response to pathogen attacks or stress, serving as crucial components of plant defense mechanisms against bacterial and fungal infections. Furthermore, recent research indicates that these compounds hold promise for improving human health, particularly in terms of potential anticancer effects that have been observed in various studies. Since our last comprehensive overview in 2016 focusing on the antiproliferative effects of these substances, brassinin and camalexin have been the most extensively studied.
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College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
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Toxicon
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Department of Animal Physiology and Toxicology, Faculty of Medicine, The John Paul II Catholic University of Lublin, 1I Konstantynów Str., 20-708, Lublin, Poland.
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