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Oxygen availability influences the incidence of testicular teratoma in mice.
Front Genet
April 2023
Department of Cell Biology, Duke University Medical Center, Durham, NC, United States.
Testicular teratomas and teratocarcinomas are the most common testicular germ cell tumors in early childhood and young men, and they are frequently found unilaterally in the left testis. In 129/SvJ mice carrying a heterozygous copy of the potent modifier of tumor incidence , a point mutation in the dead-end homolog one gene ( ), ∼70% of the unilateral teratomas arise in the left testis. We previously showed that in mice, left/right differences in vascular architecture are associated with reduced hemoglobin saturation and increased levels of the hypoxia inducible factor-1 alpha (HIF-1α) in the left compared to the right testis.
View Article and Find Full Text PDFMalignant testicular tumors in children: A single institution's 12-year experience.
Medicine (Baltimore)
July 2022
Department of Public Health and Center of Biostatistics, College of Medicine, Chang Gung University, Taiwan.
Testicular neoplasms are not commonly found in children and are a formidable threat if treated inappropriately. However, there is no consensus regarding its management. This study aimed to create a holistic picture of the interprofessional team in the management of malignant testicular tumors.
View Article and Find Full Text PDFA rare case of giant teratocarcinoma of the testis with accumulation of fluid.
Urol Case Rep
July 2022
Department of Urology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland, Plac Medyków 1, 41-200, Sosnowiec, Poland.
Testicular cancer is one of the most curable cancers. However, the course of the disease largely depends on the clinical stage at diagnosis, and there are still cases where the tumor size is large, which makes surgical treatment challenging. A 30-year-old man presented with painless, extremely enlarged scrotum.
View Article and Find Full Text PDFA Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth.
Int J Mol Sci
February 2021
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.
Cripto-1 is a member of the EGF-CFC/FRL1/Cryptic family and is involved in embryonic development and carcinogenesis. We designed a novel anti-Cripto-1 artificial antibody and assessed the recognition to the antigen and the potential to suppress the growth of cancer stem cells. First, single chain antibody clones were isolated by bio-panning with the affinity to recombinant Cripto-1 protein from our original phage-display library.
View Article and Find Full Text PDFTesticular Teratocarcinoma in a Ferret (Mustela putorius furo).
J Comp Pathol
November 2020
Veterinary Pathology Division, Joint Pathology Center, Silver Spring, Maryland, USA.
A 7-month-old male domestic ferret (Mustela putorius furo) was presented for evaluation of unilateral testicular enlargement. Microscopic examination of the left testicle revealed a neoplasm with differentiation along multiple cell lines (ectoderm, endoderm, mesoderm) including respiratory epithelium, bone and haired skin. A poorly differentiated epithelial component was dispersed throughout the neoplasm with invasion of testicular lymphatics.
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