AI Article Synopsis
- Drug-induced toxicity related proteins (DITRPs) are key players in understanding adverse drug reactions (ADRs) and drug toxicity, and the Drug-induced toxicity related protein database (DITOP) aims to provide comprehensive details about these proteins.
- Currently, DITOP houses 1501 records featuring 618 distinct DITRPs, 529 drugs/ligands, and 418 toxicity terms, which have been experimentally confirmed to interact with drugs or their metabolites.
- The database categorizes five major types of drug-induced toxicities, offers insights into the underlying molecular mechanisms, and features user-friendly access for researchers interested in toxicology data.
Article Abstract
Motivation: Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a database that is intending to provide comprehensive information of DITRPs. Currently, DITOP contains 1501 records, covering 618 distinct literature-reported DITRPs, 529 drugs/ligands and 418 distinct toxicity terms. These proteins were confirmed experimentally to interact with drugs or their reactive metabolites, thus directly or indirectly cause adverse effects or toxicities. Five major types of drug-induced toxicities or ADRs are included in DITOP, which are the idiosyncratic adverse drug reactions, the dose-dependent toxicities, the drug-drug interactions, the immune-mediated adverse drug effects (IMADEs) and the toxicities caused by genetic susceptibility. Molecular mechanisms underlying the toxicity and cross-links to related resources are also provided while available. Moreover, a series of user-friendly interfaces were designed for flexible retrieval of DITRPs-related information. The DITOP can be accessed freely at http://bioinf.xmu.edu.cn/databases/ADR/index.html.
Supplementary Information: Supplementary data are available at Bioinformatics online.
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| http://dx.doi.org/10.1093/bioinformatics/btm139 | DOI Listing |
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