Benzopyran sulfonamides as KV1.5 potassium channel blockers. | LitMetric

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Benzopyran sulfonamides as KV1.5 potassium channel blockers. | LitMetric

Benzopyran sulfonamides as KV1.5 potassium channel blockers.

John Lloyd Karnail S Atwal Heather J Finlay Michael Nyman Tram Huynh Rao Bhandaru Alexander Kover Joan Schmidt Wayne Vaccaro Mary Lee Conder Tonya Jenkins-West Paul Levesque

Bioorg Med Chem Lett

Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA.

Published: June 2007

K(V)1.5 blockers could be effective treatments specifically for atrial fibrillation, a common heart condition.
Benzopyrans serve as a useful starting point for developing strong and selective K(V)1.5 blockers.
The goal is to create medications that target the K(V)1.5 channel in the atrium, improving treatment for atrial fibrillation.

K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K(V)1.5 blockers.

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.bmcl.2007.04.020	DOI Listing

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