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Pathophysiology and management of risperidone-induced sialorrhea: case report.
Front Psychiatry
July 2023
Kern Medical, Department of Psychiatry, Bakersfield, CA, United States.
Background: Among antipsychotics, sialorrhea is most associated with clozapine, and when it occurs, it is uncomfortable, socially stigmatizing, and can contribute to medication non-adherence. Risperidone has a generally negligible muscarinic activity compared to clozapine, and yet, multiple reports of severe sialorrhea associated with risperidone have been reported.
Case Presentation: This case report describes risperidone-induced sialorrhea that was unintentionally masked by simultaneous clonidine administration that was intended to treat hypertension.
Diphenhydramine use in the treatment of risperidone-induced sialorrhea.
J Child Adolesc Psychopharmacol
June 2012
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