[Fibronectin content in wound secretions as a criterion of the course of wound healing].

The content of soluble immunoreactive fibronectin in wound exudate in 104 patients after appendectomy, laparotomy and thermal injuries was studied both in non-complicated and purulent postoperative wounds. It was shown that in the case of non-complicated wound healing fibronectin reached maximum level at the 2nd and 3rd postoperative days. At the following days the fibronectin content decreased and returned at the 4th-5th days to the first day level. In the purulent wound the amount of fibronectin in the exudate remains low in the hydratation phase rising significantly in the phase of dehydration. The described changes correlate well with the clinical signs of wound healing. The data suggest that the fibronectin content in wound exudate can be used in evaluation of wound healing, prediction of possible complications as well as in control of treatment efficiency.