Aim: This study aims to investigate whether it is possible to create a critical size bone defect in external dacryocystorhinostomy (DCR), and also at what size a defect can be considered as being critical for a successful surgical outcome.
Methods: Eighteen patients undergoing 19 external dacryocystorhinostomies, with the creation of wide osteotomies, were enrolled in this retrospective study. A 2 x 2 cm bone defect, which was considered as the critical size, was created. The postoperative structure of the bone gap was evaluated by computed tomography in axial and coronal planes at least two years after surgery. Functional patency of the ostium was confirmed with irrigation and nasal endoscopic examination.
Results: Thirteen female (72.2%) and five male (27.8%) patients underwent DCR. The patients were aged between 18 and 72 years old (mean+/-S.D.: 45.3+/-13.9). The follow-up time was between 24 and 48 months (mean 30.4 months). The areas of the gaps were between 1.21 and 4 cm(2) (mean+/-S.D.: 2.26+/-0.19).
Conclusion: The critical size bone defect (2 x 2 cm) might prevent restenosis in long term follow ups.
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http://dx.doi.org/10.1016/j.bjps.2007.02.029 | DOI Listing |
Sensors (Basel)
December 2024
School of Electrical Engineering and Automation, Hefei University of Technology, Hefei 230002, China.
LLC resonant converters have emerged as essential components in DC charging station modules, thanks to their outstanding performance attributes such as high power density, efficiency, and compact size. The stability of these converters is crucial for vehicle endurance and passenger experience, making reliability a top priority. However, malfunctions in the switching transistor or current sensor can hinder the converter's ability to maintain a resonant state and stable output voltage, leading to a notable reduction in system efficiency and output capability.
View Article and Find Full Text PDFSensors (Basel)
December 2024
School of Instrument and Electronics, North University of China, Taiyuan 030051, China.
Tire pressure monitoring systems (TPMSs) are essential for maintaining driving safety by continuously monitoring critical tire parameters, such as pressure and temperature, in real time during vehicle operation. Among these parameters, tire pressure is the most significant, necessitating the use of highly precise, cost-effective, and energy-efficient sensing technologies. With the rapid advancements in micro-electro-mechanical system (MEMS) technology, modern automotive sensing and monitoring systems increasingly rely on MEMS sensors due to their compact size, low cost, and low power consumption.
View Article and Find Full Text PDFPharmaceutics
December 2024
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Background: The clinical efficacies of anticancer drugs are limited by non-selective toxic effects on healthy tissues and low bioavailability in tumor tissue. Therefore, the development of vehicles that can selectively deliver and release drugs at the tumor site is critical for further improvements in patient survival.
Methods: We prepared a CEC nano-drug delivery system, CEC@ZIF-8, with a zeolite imidazole framework-8 (ZIF-8) as a carrier, which can achieve the response of folate receptor (FR).
Pharmaceutics
November 2024
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Kanagawa, Japan.
Extracellular vesicles (EVs), including exosomes, are promising pharmaceutical modalities. They are purified from cell culture supernatant; however, the preparation may contain EVs with the desired therapeutic effects and different types of EVs, lipoproteins, and soluble proteins. Evaluating the composition of particulate impurities and the levels of protein impurities in final preparations is critical for quality control.
View Article and Find Full Text PDFPharmaceutics
November 2024
Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Lipid nanoparticles (LNPs) have shown promise as a delivery system for nucleic acid-based therapeutics, including DNA, siRNA, and mRNA vaccines. The immune system plays a critical role in the response to these nanocarriers, with innate immune cells initiating an early response and adaptive immune cells mediating a more specific reaction, sometimes leading to potential adverse effects. Recent studies have shown that the innate immune response to LNPs is mediated by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), which recognize the lipid components of the nanoparticles.
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