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Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis.
BMC Musculoskelet Disord
January 2025
General Hospital of Ningxia Medical University, Ningxia, 750004, China.
The case of Lumbar spinal stenosis (LSS) combined with tophi due to gout is rarely reported. In the course of our clinic work, we encountered a young male patient who was diagnosed with a history of gout for 5 years and was targeted as LSS combined with gouty tophi, and we would like to share this case. In addition, in order to further investigate the deep mechanism of LSS associated with gout, we obtained the intersecting genes of the two diseases based on a machine learning approach by obtaining the dataset GSE113212 related to LSS from the Gene Expression Omnibus (GEO) database, and the genes related to gout from the human gene database.
View Article and Find Full Text PDFExploration of molecular biomarkers in ankylosing spondylitis transcriptomics.
Front Immunol
January 2025
Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Article Synopsis
- Ankylosing spondylitis (AS) is a chronic condition characterized by inflammation of the spine and sacroiliac joints, leading to potential delays in diagnosis and treatment due to its non-specific early symptoms, underscoring the need for new biomarkers.
- Two datasets (GSE73754 and GSE25101) were analyzed to identify key genes related to AS, using methods like differential expression analysis and LASSO regression, which resulted in the discovery of five significant genes (ACSL1, SLC40A1, GZMM, TRIB1, XBP1) that showed strong diagnostic potential.
- The study also revealed correlations between these genes and immune cell infiltration as well as clinical indicators, with notable links between
Optimizing gout treatment: A comprehensive review of current and emerging uricosurics.
Joint Bone Spine
November 2024
Division of Rheumatology, Department of Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, 84132 Utah, United States; Department of Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, 84132 Utah, United States.
Gout is the most common inflammatory arthritis, affecting approximately 5.1% of adults in the United States (US) population. Gout is a metabolic and autoinflammatory disease.
View Article and Find Full Text PDFExtensive tophaceous gout with subcutaneous deposits in the buttocks.
Joint Bone Spine
November 2024
Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China. Electronic address:
Prevalence of and Risk Factors for Hyperuricemia in Urban Chinese Check-Up Population.
Int J Endocrinol
October 2024
Department of Nephrology, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Article Synopsis
- * Findings show that in 2021, the overall prevalence was 13.6%, with significantly higher rates for men (24.3%) compared to women (2.6%), and marked regional differences across the country.
- * Male sex, older age, and certain health conditions like hypertension and obesity are linked to higher hyperuricemia prevalence, highlighting the need for increased awareness and management of this issue in China's developed areas.
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