AI Article Synopsis
- Histiocytosis encompasses rare disorders in the reticuloendothelial system, with eosinophilic granuloma being the least severe and often solitary or multiple.
- Eosinophilic granuloma typically affects bones, particularly the mandible when involving the jaws, and is treated through surgery, radiotherapy, chemotherapy, and steroids, sometimes showing spontaneous regression.
- A case is reported of a 6.5-year-old with Langerhans cell histiocytosis who experienced initial regression of a solitary eosinophilic granuloma in the mandible, but rapidly recurred and resulted in a fatal outcome despite aggressive treatment.
Article Abstract
Histiocytosis is a term applied to a group of rare disorders of the reticuloendothelial system. Eosinophilic granuloma, the most benign and localized of the three Langerhans cell histiocytosis entities, may be solitary or multiple. Eosinophilic granuloma can affect almost any bone, but commonly involves the mandible when the jaws are affected. Conventional treatment of LCH is with surgery, radiotherapy, chemotherapy and steroid injections, alone or in combination. Spontaneous regression of localized disease has also been reported. We report a six and a half-year-old patient with Langerhans cell histiocytosis--solitary eosinophilic granuloma of the mandible that initially regressed but rapidly recurred even after radical treatment and had a fatal outcome.
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| http://dx.doi.org/10.4103/0378-6323.31899 | DOI Listing |
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