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Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases.
SAGE Open Med Case Rep
December 2024
Division of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have differing treatment regimens and prognoses. Distinction between severe cutaneous adverse reactions, particularly in the early stages of disease, can be difficult, and overlapping conditions have been reported in the literature.
View Article and Find Full Text PDFCase Report: Multi-targeted therapy in the treatment of severe toxic epidermal necrolysis.
Front Pediatr
November 2024
Department of Paediatrics, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China.
Article Synopsis
- A 10-year-old boy developed severe toxic epidermal necrolysis due to trimethoprim-sulfamethoxazole and was successfully treated with a multi-targeted therapy approach.
- The treatment team included specialists from pediatrics, dermatology, otolaryngology, urology, wound care, pain management, dietetics, and psychology, demonstrating a comprehensive care model.
- Key interventions included intravenous immunoglobulin, steroids, cyclosporin A for eye issues, amniotic membrane transplantation, and etanercept for steroid management, leading to recovery without side effects by day 13.
Objective: The most common severe exfoliative condition is toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, for which patients may sometimes require admission to hospital burns units. This study analyses the experience of the authors and results in this condition at the Cruces University Hospital in Bilbao, Spain.
Method: Over the last 22 years, the authors carried out a retrospective analytical observational study of TEN cases at the hospital and analysed risk factors including age, associated comorbidities, percentage of body surface area affected, positive bacterial culture, and treatment strategies used to assess their potential influence on prognosis.
TNF-α inhibitors as therapy for drug-induced severe cutaneous adverse reactions: a case series.
J Dermatolog Treat
December 2024
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- - Severe cutaneous adverse reactions (SCARs) like AGEP, DRESS, SJS, and TEN are serious conditions associated with high mortality rates, and while corticosteroids are commonly used for treatment, their effectiveness is uncertain due to infection risks.
- - Recent studies have introduced TNF-α inhibitors, which have shown promise in treating SCARs, with a report indicating that four patients (21-54 years old) treated with these inhibitors had successful recoveries without complications.
- - The TNF-α inhibitors work by targeting the harmful immune response linked to SCARs, but more large-scale trials are needed to confirm their efficacy and ensure a safe approach to their use.
Widespread rash in a 45-year-old woman after moxifloxacin administration.
JAAD Case Rep
November 2024
Dermatology Unit and Burn Center, AUSL Romagna, Cesena Hospital, Cesena, Italy.
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