AI Article Synopsis
- The study aimed to examine the genetic impacts on workers who are occupationally exposed to mercury (Hg).
- Significant differences in genetic markers, such as micronucleus rate (MNR) and micronucleated cells rate (MCR), were found between exposed workers and control subjects, indicating a higher level of genetic damage in the workers.
- Although the study showed elevated levels of certain genetic effects in those exposed to mercury, the mutation frequencies in specific genes (hprt and TCR) did not significantly differ from those in the control group.
Article Abstract
Objective: To investigating genetic effects of workers occupationally exposed to mercury (Hg).
Methods: The peripheral lymphocytes from 20 workers exposed to mercury and 20 controls were measured with micronucleus test, comet assay, hrpt gene mutation test and TCR gene mutation test.
Results: The mean micronuclei rate(MNR) and mean micronucleated cells rate(MCR) in 20 workers were (5.90 +/- 0.91) per thousand and (5.30 +/- 0.81) per thousand, respectively while MNR and MCR in controls were (1.50 +/- 0.47) per thousand and (1.30 +/- 0.31) per thousand respectively, The difference of MNR and MCR between workers and controls was very significant (P < 0.01). The mean tail length (MTL) of workers and controls were (3.16 +/- 0.31) and (0.99 +/- 0.07) microm, respectively. The mean tail moment (MTM) of workers and controls were 1.63 +/- 0.22 and 0.39 +/- 0.03, respectively, There was a significant difference in MTL and MTM between workers and controls(P < 0.01). When the average mutation frequencies (Mfs-hprt) of hprt and (Mfs-TCR) of TCR of workers were compared with those of controls, there were not significant difference (P > 0.05).
Conclusion: The results of the investigation indicated that the adverse genetic effects in workers occupationally exposed to mercury could be detected.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Microplastics aggravate the adverse effects of methylmercury than inorganic mercury on zebrafish (Danio rerio).
Environ Pollut
December 2024
Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, And Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Beijing, 100081, China. Electronic address:
The potential health risks of microplastics (MPs) and their combined exposure with heavy metals such as mercury (Hg) in aquatic environment are increasingly concerned recently. In this work, zebrafish embryos were exposed to different levels of polystyrene microplastics (PS-MPs, ∼0.1 μm) coupled with Hg(II) or/and MeHg at 20 μg/L, to investigate the tissue biodistribution and accumulation of PS-MPs and Hg species, and their interaction, as well as embryo toxicity, oxidative stress and metabolic profiles.
View Article and Find Full Text PDFRecent advances in the study of mercury biogeochemistry in Arctic permafrost ecosystems.
Sci Total Environ
December 2024
Centro de Química Estrutural, Institute of Molecular Sciences and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal; Centre d´études nordiques (CEN), Université Laval, Québec, QC G1V 0A6, Canada. Electronic address:
Permafrost predominates in polar and high mountain regions, encompassing nearly 15 % of the exposed land in the Northern Hemisphere. It denotes soil or rock that remains at or below 0 °C for the duration of at least two consecutive years. These frozen soils serve as a barrier to contaminants that are stored and accumulated in permafrost over extended periods of time.
View Article and Find Full Text PDFHost-microbiota interplay in arsenic metabolism: Implications on host glucose homeostasis.
Chem Biol Interact
December 2024
Chemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India. Electronic address:
Arsenic (As), a naturally occurring element with unique properties, has been recognized as the largest mass poisoning in the world by the World Health Organization (WHO). Approximately 200 million people worldwide are exposed to toxic levels of arsenic due to natural and anthropogenic activities. This widespread exposure necessitates a deeper understanding of microbe-arsenic interactions and their potential influence on host exposure and health risks.
View Article and Find Full Text PDFLactational exposure of human infants to metal(loid)s in Sub-Saharan Africa and Mediterranean Europe: A systematic review and meta-analysis.
Curr Res Toxicol
November 2024
African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Port Harcourt 5323, Rivers State, Nigeria.
Breast milk, a fundamental component of infant nutrition, may serve as a reservoir for various metal(loid)s, which could pose significant health risks to infants of mothers exposed to toxic metals. Human exposure levels to metal(loid)s vary across regions, influenced by differences in diet, lifestyle, and environmental factors. This systematic review compares metal(loid) concentrations in breast milk from Sub-Saharan Africa (SSA) and Mediterranean Europe (Med.
View Article and Find Full Text PDFUpregulation of caspase-3, oxidative stress, neurobehavioural and histological alterations in mercury chloride-exposed rats: role of aqueous Allium sativum bulb extract.
J Mol Histol
December 2024
Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin, Edo State, Nigeria.
Mercury is a highly toxic metal that causes a variety of neurological disorders through oxidative stress. Allium sativum, a cooking spice in diverse cultures around the world, has a long history of medicinal use due to its rich antioxidant constituents. This study was designed to evaluate the protective activity of aqueous Allium sativum bulb extract (ASBE) on mercuric chloride (HgCl)-induced neurotoxicity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!