AI Article Synopsis
- The study aims to evaluate the effectiveness of an ultrasonic system in diagnosing the severity of liver fibrosis in chronic hepatitis B patients.
- It involved analyzing 110 patients using a scoring system based on seven ultrasound parameters, resulting in a strong correlation with histological findings (r=0.824, P < 0.001).
- The combined ultrasound scoring and discriminating function achieved high specificity (85%-90%) and accuracy (77%-84%) in detecting liver fibrosis stages, indicating its potential as a reliable noninvasive diagnostic tool.
Article Abstract
Objective: To discuss the diagnostic value of an ultrasonic assessing system for detecting the severity of hepatic fibrosis in patients with chronic hepatitis B (CHB).
Methods: Ultrasonographic variables were analyzed in 110 CHB patients. An ultrasonic semi-quantitative scoring system using seven ultrasonic morphologic parameters, a Fisher discriminating function and three quantitative ultrasonic parameters was developed. The performance of these methods was also studied and compared.
Results: The areas under the curve of the scoring system for different liver fibrosis stages were >or= S2: 0.946, >or= S3: 0.914, and S4: 0.915. The total score was well correlated with the histological stage of fibrosis (r=0.824, P < 0.001). There was a significant difference between the stages of fibrosis. The accuracy of the Fisher discriminating function for identifying three study endpoints was 76.5%, 78.2% and 67.3%. Combining the ultrasonic scoring system and the discriminating function, the specificity was 85%-90% and the accuracy was 77%-84%.
Conclusion: Our ultrasonic semi-quantitative scoring system is a noninvasive method for quantitating liver fibrosis. If it is used together with a discriminating function, the accuracy of diagnosing liver fibrosis can be significantly increased.
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