Male rodents display greater systemic morphine antinociception than females which show their most marked effects during late diestrus or proestrus. Morphine (1-2.5 mug) antinociception on the tail-flick test elicited from the ventrolateral periaqueductal gray was examined across estrus phases in female relative to male rats. Morphine antinociception was greatest in magnitude and potency in males followed by females tested during the proestrus phases relative to estrus and met-diestrus. These data confirm morphine's systemic effects, implicate the ventrolateral periaqueductal gray in estrus phase-mediated effects, and underscore the control of the phase of the estrus cycle in examining sex differences in opioid antinociception.
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