Purpose: To evaluate fundus photographic image analysis combining automated detection of red lesions, bright lesions, and image quality as a means of identifying treatment-requiring diabetic retinopathy in a screening population of diabetic patients.
Methods: This was a retrospective cross-sectional study of 106 patients from a diabetic retinopathy screening clinic referred for photocoagulation treatment in the period from January 1996 to May 2002 on the basis of mydriatic 60-degree 35-mm color transparency fundus photography. One fovea-centered fundus photograph and one centered nasal of the optic disk from each of a subject's two eyes was selected for digitization and analyzed using a previously tested computerized red-lesion detection algorithm in combination with a new algorithm for detection of bright lesions and image quality. The algorithm was calibrated on an independent set of fundus photographs.
Results: Automated red-lesion detection identified 104 of 106 patients requiring photocoagulation treatment, whereas bright-lesion detection identified only 91 of the 106 patients. Two patients who were not identified by either lesion detection algorithm were automatically detected as having poor image quality in one or both eyes. In the study sample, the risk of missing treatment-requiring retinopathy patients from being detected was 0.0% (estimated CI(95) 0.0-3.4%).
Conclusions: The combination of automated detection of red lesions and poor image quality identified all treatment-requiring diabetic retinopathy patients in the study sample. No additional information was contributed by the automated bright-lesion detection.
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http://dx.doi.org/10.1080/02713680701215587 | DOI Listing |
JCI Insight
January 2025
Dianne Hoppes Nunnally Laboratory Research Division, Joslin Diabetes Center, Boston, United States of America.
Background: We aimed to characterize factors associated with the under-studied complication of cognitive decline in aging people with long-duration type 1 diabetes (T1D).
Methods: Joslin "Medalists" (n = 222; T1D ≥ 50 years) underwent cognitive testing. Medalists (n = 52) and age-matched non-diabetic controls (n = 20) underwent neuro- and retinal imaging.
Jpn J Ophthalmol
January 2025
Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya Koshigaya, Saitama, 343-8555, Japan.
Purpose: To compare the amplitudes and implicit times of the oscillatory (OPs) of the full-field electroretinograms (ERGs) to those of the 30 Hz flicker ERGs in differentiating eyes with diabetic retinopathy (DR) from normal eyes.
Study Design: Single-center observational study.
Methods: Full-field ERGs were recorded in 55 patients with Type 2 diabetes mellitus (DM) and 20 normal control subjects.
Heliyon
January 2025
Information Technology Department, Technical College of Informatics-Akre, Akre University for Applied Sciences, Kurdistan Regain, Iraq.
Deep Learning (DL) has significantly contributed to the field of medical imaging in recent years, leading to advancements in disease diagnosis and treatment. In the case of Diabetic Retinopathy (DR), DL models have shown high efficacy in tasks such as classification, segmentation, detection, and prediction. However, DL model's opacity and complexity lead to errors in decision-making, particularly in complex cases, making it necessary to estimate the model's uncertainty in predictions.
View Article and Find Full Text PDFLancet Reg Health West Pac
February 2025
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.
Background: To date, comprehensive data on the distribution of chronic kidney disease (CKD), the most prevalent comorbidity in diabetes, among Chinese adults with diabetes is lacking. Additionally, research gaps exist in understanding the association between CKD and cardiovascular health (CVH), an integrated indicator of lifestyle and metabolic control, within a nationwide sample of Chinese adults with diabetes.
Methods: A nationally community-based cross-sectional survey was conducted in 2018-2020.
Health Technol Assess
January 2025
Centre for Reviews and Dissemination, University of York, York, UK.
Background: Non-proliferative and proliferative diabetic retinopathy are common complications of diabetes and a major cause of sight loss. Anti-vascular endothelial growth factor drugs represent a treatment option for people with diabetic retinopathy and are routinely used to treat various other eye conditions. However, anti-vascular endothelial growth factor drugs are expensive relative to current care options, and it is unclear whether this additional cost is justified when the immediate risk of vision loss is lower compared to patients with more aggressive ophthalmological conditions.
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