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Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.
Pain
December 2024
Palo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Previous preclinical and translational studies suggest that tissue trauma related to bony fracture and intervertebral disk disruption initiates the formation of pronociceptive antibodies that support chronic musculoskeletal pain conditions. This study tested this hypothesis in the monosodium iodoacetate (MIA) mouse model of osteoarthritis (OA) and extended the findings using OA patient samples. Monosodium iodoacetate was injected unilaterally into the knees of male and female wild-type (WT) and muMT mice (lacking B cells) to induce articular cartilage damage.
View Article and Find Full Text PDFCharacterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations.
J Anim Sci Biotechnol
January 2025
Center for Animal Nutrition and Welfare, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria.
Background: The objective was to characterize the colostrum proteome of primiparous Holstein cows in association with immunoglobulin G (IgG) content. Immediately after calving, colostrum samples were collected from 18 cows to measure IgG concentration. Based on colostrum IgG content, samples were classified through cluster analysis and were identified as poor, average, and excellent quality.
View Article and Find Full Text PDFConstruction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.
Virol J
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, PR China.
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections. The Vero cell line has been widely used in vaccine production, particularly in the preparation of viral vaccines, including poliovirus vaccines and EV71 vaccines.
View Article and Find Full Text PDFEvaluating energy consumption patterns in novel foamed ternary alkali-activated masonry blocks.
Sci Rep
January 2025
Sustainability Solutions Research Lab, Faculty of Engineering, University of Pannonia, Egyetem Str. 10, Veszprém H, 8200, Veszprém, Hungary.
This study endeavors to tackle the energy requirements of the building sector by employing passive design strategies. However, there exists a dearth of comprehension regarding the energy efficiency performance of foamed alkali-activated materials. To bridge this research gap, the study proposes a solution in the form of a thermally proficient wall material crafted from ceramic tile dust (CTD), class C fly ash (FA), and Ground Granulated Blast-Furnace Slag (GGBS), all of which are industrial by-products.
View Article and Find Full Text PDFPassive transfer of patient-derived anti-nephrin autoantibodies causes a podocytopathy with minimal change lesions.
J Clin Invest
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Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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