AI Article Synopsis
- Pentamidine is used as a second-line treatment for leishmaniasis, but its action and resistance are not fully understood.
- Researchers discovered that the ABC protein PRP1 (ABCC7) in Leishmania sp. can make the parasites resistant to pentamidine.
- The study highlights the role of PRP1 in providing this resistance during the intracellular stage of the parasite’s life cycle.
Article Abstract
Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932501 | PMC |
| http://dx.doi.org/10.1128/AAC.00404-07 | DOI Listing |
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