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Identification of novel PANDAR protein interaction partners involved in splicing regulation.
Sci Rep
February 2018
Chemical Genomics Centre of the Max-Planck Society, Otto-Hahn-Str. 11, 44227, Dortmund, Germany.
Interactions of long non-coding RNAs (lncRNA) with proteins play important roles in the regulation of many cellular processes. PANDAR (Promotor of CDKN1A Antisense DNA damage Activated RNA) is a lncRNA that is transcribed in a p53-dependent manner from the CDKN1A promoter and is involved in the regulation of proliferation and senescence. Overexpression of PANDAR has been observed in several tumor species and correlated with a poor prognosis for patient survival rate.
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Department of Chemistry and Biochemistry, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA.
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