28 male Long-Evans rats prepared with lesions of the middle cerebral artery displayed deficits in spatial navigational learning in a simple version of the Morris Water Maze task not seen in animals prepared with the same injury but administered 4 treatments with topiramate after surgery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2466/pr0.100.1.164-166 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice.
Heliyon
December 2024
Department of Biomedical Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Khyber Pakhtunkhwa, Pakistan.
Morphine belongs to the class of opioids and is known for its potential to cause dependence and addiction, particularly with prolonged use. Due to the associated risks, caution must be taken when prescribing and limiting its clinical use. Overexpression of N-methyl-D-aspartate (NMDA) receptors, nitric oxide and cGMP pathway has been implicated in exacerbate the development of morphine dependence and withdrawal.
View Article and Find Full Text PDFComparative effects of topiramate and naltrexone on neural activity during anticipatory anxiety in individuals with alcohol use disorder.
Alcohol Alcohol
November 2024
Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2050, Australia.
Article Synopsis
- - Topiramate has shown effectiveness in reducing alcohol use and possibly lowering anxiety severity in patients with alcohol use disorder (AUD), compared to naltrexone, another medication used for AUD.
- - In a study with 42 treatment-seeking AUD patients, participants were given either topiramate or naltrexone for 12 weeks, and their neural responses to an anxiety-inducing task were measured using fMRI after 6 weeks of treatment.
- - The study found no major differences in brain activation between the two treatment groups, but it noted that changes in anxiety levels were linked to the brain's response to threat cues, providing insights into how these medications may work.
Polymorphism and Pharmacological Assessment of Carbamazepine.
Int J Mol Sci
September 2024
Graduate Program in Pharmaceutical Sciences, Evangelical University of Goiás, Anapolis 75083-515, GO, Brazil.
This work provides insight into carbamazepine polymorphs (Forms I, II, III, IV, and V), with reports on the cytoprotective, exploratory, motor, CNS-depressant, and anticonvulsant properties of carbamazepine (CBZ), carbamazepine formulation (CBZ-F), topiramate (TOP), oxcarbazepine (OXC), and diazepam (DZP) in mice. Structural analysis highlighted the significant difference in molecular conformations, which directly influence the physicochemical properties; and density functional theory description provided indications about CBZ reactivity and stability. In addition to neuron viability assessment in vitro, animals were treated orally with vehicle 10 mL/kg, as well as CBZ, CBZ-F, TOP, OXC, and DZP at the dose of 5 mg/kg and exposed to open-field, rotarod, barbiturate sleep induction and pentylenetetrazol (PTZ 70 mg/kg)-induced seizure.
View Article and Find Full Text PDFFenofibrate ameliorates nitroglycerin-induced migraine in rats: Role of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways.
Eur J Pharmacol
August 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562, Cairo, Egypt.
Migraine, a debilitating neurological condition, significantly affects patients' quality of life. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist approved for managing dyslipidemia, has shown promise in treating neurological disorders. Therefore, this study aims to investigate the protective effects of fenofibrate against nitroglycerin (NTG)-induced chronic migraine in rats.
View Article and Find Full Text PDFThe combined pioglitazone and topiramate therapy for management of pediatric patients with severe MASLD.
Saudi J Gastroenterol
July 2024
Department of Pediatrics, Division of Pediatric Gastroenterology, University of Kentucky College of Medicine and Kentucky Children's Hospital, Lexington, Kentucky, USA.
Background: Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common cause of chronic hepatitis in adult and pediatric patients. Adolescents with severe MASLD can demonstrate a more aggressive disease phenotype as they more commonly develop liver fibrosis than BMI matched adults. Therefore, MASLD is the fastest growing indication for liver transplants in young adults.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!