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http://dx.doi.org/10.1007/s00210-007-0160-z | DOI Listing |
Kidney Int
November 2010
University of Zurich, Institute of Physiology, Zurich, Switzerland.
J Nephrol
April 2010
Interdepartmental Center for Clinical Research, Second University of Naples, Naples - Italy.
Klaus Hierholzer (1929-2007) dissected various functions influenced by steroids in the distal tubule and showed that aldosterone in low doses reversed the sodium and potassium transport defect in adrenalectomized rats, through a rapid activation of Na+,K+-ATPase. Subsequent studies addressed the role of 11-beta-hydroxysteroid oxidoreductase (11-HSD) and showed that the undisturbed functioning of 11-HSD is a prerequisite for selective mineralocorticosteroid regulation of epithelial transport. Another set of original experiments showed that 11-HSD was equally important in the distal colon, thus establishing that the large intestine acts in parallel with the distal nephron.
View Article and Find Full Text PDFNeuropsychiatr
January 2008
Universitätsklinik für Psychiatrie, Medizinische Universität Innsbruck.
Naunyn Schmiedebergs Arch Pharmacol
June 2007
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Otto-Krayer-Haus, Albertstrasse 25, 79104, Freiburg im Breisgau, Germany.
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