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The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor.
Andrology
March 2022
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation.
Objectives: This study aimed to investigate whether changes in brain TPH2 levels were associated with PE and to explore the effects of acute administration of dapoxetine on TPH2 expression in the brain of rats with rapid ejaculation.
Materials And Methods: Based on the ejaculation frequency, the male rats were split into three groups: "rapid," "normal," and "sluggish" ejaculators.
Expression of brain-derived neurotrophic factor in rapid ejaculator rats: A further study.
Andrologia
September 2021
Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Limited evidence has indicated that brain-derived neurotrophic factor (BDNF) may be involved in the neurobiology of premature ejaculation (PE). This study aimed to investigate BDNF levels in the central and peripheral nervous systems of a rapid ejaculation model. Eighteen male rats were selected and classified as 'sluggish', 'normal' and 'rapid' ejaculators on the basis of ejaculation frequency during copulatory behavioural tests.
View Article and Find Full Text PDFSemen pH and its correlation with motility and count - A study in subfertile men.
JBRA Assist Reprod
April 2021
Santhathi Centre for Reproductive Medicine, Near Mangalore Nursing Home Upper Bendoor, Mangaluru, India.
Objective: The current study was aimed at correlating semen pH with motility and count to understand the significance of semen buffering system.
Methods: The semen samples were collected from men who visited the clinic with infertility problems. Determination of semen pH, sperm motility and count were done according to the WHO laboratory manual, 2010 standards.
Semen analysis of subfertility caused by testicular carcinoma.
Int J Reprod Biomed
July 2020
Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Background: Infertility is a common problem in testicular cancer. Affected men often decide to undergo sperm banking before chemo/radiotherapy. The cumulative effects of therapy can considerably reduce fertility.
View Article and Find Full Text PDFMitochondria, spermatogenesis, and male infertility - An update.
Mitochondrion
September 2020
Division of Endocrinology, Central Drug Research Institute, Lucknow, India. Electronic address:
The incorporation of mitochondria in the eukaryotic cell is one of the most enigmatic events in the course of evolution. This important organelle was thought to be only the powerhouse of the cell, but was later learnt to perform many other indispensable functions in the cell. Two major contributions of mitochondria in spermatogenesis concern energy production and apoptosis.
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