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Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II.
Curr Nutr Rep
January 2025
Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand.
Purpose Of Review: Berries are a great source of fiber, polyunsaturated fatty acids, and beneficial secondary metabolites (polyphenols). Various phytochemicals present in berries (glycosidic-linked flavonoids, anthocyanins, etc.) provide potential health benefits to consumers.
View Article and Find Full Text PDFThe effect of long-chain n-3 PUFA on liver transcriptome in human obesity.
Prostaglandins Leukot Essent Fatty Acids
December 2024
Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Austria; Department of Medicine III and Karl Landsteiner Institute for Metabolic Diseases and Nephrology, Clinic Hietzing, Vienna, Austria. Electronic address:
Background And Aims: Obesity is associated with a higher risk of severe diseases such as atherosclerotic cardiovascular disease, type 2 diabetes mellitus (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD). Polyunsaturated fatty acids, of the omega-3 family (n-3 PUFA), have been shown to reduce adipose tissue inflammation in obesity, as well as to have lipid-lowering effects and improve insulin sensitivity. However, direct effects on liver transcriptome in humans have not been described.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Pacific Brain Health Center, Pacific Neuroscience Institute Foundation, Santa Monica, CA, USA.
Background: Brain accumulation of amyloid-ß (Aß) in plaques and neurons is the cause of AD neuropathology that is opposed by autologous monocyte/macrophages (MMs) in health but this defense fails in AD.
Method: RNAseq, immunochemistry of the brain, immunofluorescence, and confocal microscopy of macrophages.
Result: In the AD brain, MMs shuttle Aß from parenchyma to vessels, which develop vasculitis, causing amyloid-related imaging abnormalities (ARIAs).
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia, Melbourne, VIC, Australia.
Background: Allelic variation in apolipoprotein E (APOE) is by far the greatest contributor to Alzheimer's disease (AD) after age, but the mechanisms underlying how APOE impacts on the pathology of AD remain undefined. While most research is focusing on mechanisms associated with the presence of the APOE risk allele, several aspects of APOE biology remain poorly understood. In particular, the physiological relevance of APOE receptors and their impact on disease progression have been overlooked.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California Davis Medical Center, Sacramento, CA, USA.
Background: Inflammation is crucial in Alzheimer's Disease (AD), where oxidized lipid derivatives of polyunsaturated fatty acids (PUFAs), i.e., oxylipins, are potent modulators.
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