In our continued screening on bioactive constituents from marine-derived fungi, two novel compounds containing a rare spiral-lactone skeleton were isolated from lyophilized culture broth of the marine-derived fungus Penicillium sp. The structures of penisporolides A and B were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. The relative stereochemistries of the compounds were assessed by analysis of NOESY data together with the comparison with data from previous literatures.
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