A new carbazole alkaloid, streptoverticillin, and a new 2-azetidinone, streptoverticillinone, along with three known cyclodipeptides were isolated from the mycelial solid culture of Streptoverticillium morookaense. Their structures were elucidated by analysis of 1D and 2D NMR, mass spectra and optical rotation data. Two new compounds exhibited antifungal activity against Peronophythora litchii.
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http://dx.doi.org/10.1038/ja.2007.19 | DOI Listing |
J Nat Prod
November 2023
Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
Eleven new phenyltetracenoid polyketides, streptovertimycins U () and V (), 14-bromo-streptovertidione (), streptovertimycins W-Y (-), and streptovertimycins Z-Z (-, together with the known congeners fasamycins R () and S () and accramycins A () and B (), were isolated from the NaBr-supplemented rice-grown cultures of SC1169. Their structures were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and theoretical computations of ECD spectra. Compounds and are methylene-bridged dimers of accramycin A, and compounds and - are brominated fasamycin congeners.
View Article and Find Full Text PDFJ Nat Prod
June 2021
Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
Formicapyridine-type racemates, streptovertidines A () and B (), a 7,24--fasamycin, streptovertidione (), and the fasamycin-type streptovertimycins I-T (-), together with 13 known fasamycin congeners (-), were isolated from soil-derived SC1169. Their structures were elucidated by extensive spectroscopic analysis and theoretical computations of ECD spectra. The fasamycin-type compounds , -, , and exhibited activity against the drug-resistant bacteria MRSA and VRE (MIC: 1.
View Article and Find Full Text PDFNat Prod Res
July 2022
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou China.
Three new compounds, including 6-methoxy-3,4,5,7-tetramethylisochromane-3,8-diol (), 3,4,5,7-tetramethylisochromane-3,6,8-triol (), streptimidone derivative (), along with ten known compounds (-) were isolated from the strain Sm4-1986. Their chemical structures were established based on the information from UV, IR, NMR (H NMR, C NMR, H-H COSY, HSQC, HMBC, NOESY), and mass spectroscopic. Moreover, all the isolated new compounds were evaluated for antibacterial activities (.
View Article and Find Full Text PDFMicrobiol Resour Announc
July 2020
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China
Here, we describe the genome of DSM 40503, an 8-azaguanine-producing strain. The genome is the basis for future study and presents an underexplored taxonomy and biosynthetic potential, which expands our understanding of the diversity of microorganisms that produce nitrogen heterocyclic compounds.
View Article and Find Full Text PDFJ Antibiot (Tokyo)
May 2020
Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Digital Botanical Garden, South China Botanical Garden, Chinese Academy of Sciences, Lab Building No. 2, CAS, Xingke Road 723, Tianhe District, Guangzhou, 510650, PR China.
Eight new fasamycin-type polyketides, streptovertimycins A-H (1-8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1-8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group.
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