AI Article Synopsis
- The study aims to compare the effects of three beta-blockers (carvedilol, metoprolol, and propranolol) on gap junction structure in rats with heart damage due to ischemia and reperfusion.
- Rats were divided into five groups, including one control and four that underwent simulated heart damage followed by treatments with the different beta-blockers.
- The findings revealed that ischemia and reperfusion altered gap junctions, but beta-blocker treatment, particularly carvedilol, significantly improved their structure compared to the untreated group.
Article Abstract
Objective: To compare the effects of carvedilol, metoprolol and propranolol on myocardial gap junction (GJ) structure in rat with myocardial ischemia and reperfusion injury.
Methods: Rats were divided randomly into five groups: sham operation group (SO), myocardial ischemia and reperfusion group (IR), IR + carvedilol group (CV), IR + metoprolol group (MT), and IR + propranolol group (PP). The left anterior descending branch was ligated for 30 minutes and reperfused for 4 hours (IR). After 4 h reperfusion, the distribution and composition of gap junctional connexin 43 (CX43) were observed by immunofluorescence and laser scanning confocal microscopy (LSCM), and the quantification of CX43 was measured by LSCM.
Result: Compared with SO group, IR resulted in abnormal distribution and composition of CX43-GJ and the impairment of CX43-GJ was significantly attenuated by CV, MT and PP treatments with the best effect observed in CV group (P<0.05 vs. MT and PP).
Conclusion: These results suggest that beta-blockers, especially, carvedilol, could significantly attenuate IR induced CX43-GJ impairment.
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