Connections between mental disorders and epilepsy have been perceived for a long period of time. Despite numerous investigations into this problem, it still is not fully understood in regard to the fact that in epilepsy the psychoses are situated at the intersection of neurology and psychiatry and the same phenomena, if presenting the psychotic syndrome, are often described in different terms. The most serious diagnostic as well as therapeutic problems are psychotic disorders which coexist with epileptic seizures. The goal of this paper was to present the case history of a patient, who was diagnosed with a psychotic disorder caused by partial complex seizures. The patient presented was hospitalized many times and several different neuroleptic treatments were used unsuccessfully. During the course of the illness many severe episodes of psycho-motor agitation connected with auto-aggressive acts were observed. It was not until an EEG - Holter test was performed and antiepileptic drugs were added to the treatment which aided in making the correct diagnosis. This enabled the patient to return to his highest level of functioning since the onset of the illness.
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J Child Psychol Psychiatry
January 2025
Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early-onset schizophrenia spectrum disorders. This research review looks at the state-of-the-art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and adolescents to findings from psychosis risk syndrome research, to evidence on early-onset psychotic disorders. The review also looks at new opportunities to capture psychosis risk in childhood and adolescence, including opportunities for early intervention, identifies important unanswered questions, and points to future directions for prevention research.
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Brunel University London, London, United Kingdom.
Background: Psychosis occurs in 30-40% of individuals with AD. New insights into disease mechanisms may lead to novel pharmacological targets and treatments. Previous studies have focused on bulk tissue analysis with limited results.
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December 2024
University of Exeter, Exeter, Devon, United Kingdom.
Background: Psychosis (broadly delusions and hallucinations) has a cumulative disease prevalence of around 40% in Alzheimer's disease (AD). The epigenomic, genomic, and neuropathological data provide powerful evidence that AD+P has a distinct neurobiological profile. Here, we used the weighted gene co-expression network analysis (WGCNA) method to investigate DNA methylation associated with AD+P in the dorsolateral prefrontal cortex of 153 post-mortem brain samples.
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December 2024
University of Exeter, Exeter, United Kingdom.
Background: When assessed in the Mild Behavioral Impairment (MBI) framework, late-life onset psychotic like symptoms (MBI-psychosis) are associated with incident cognitive decline and dementia. One approach to examining the genetic basis of this association, is to use Polygenic Risk Scores (PRS) to determine whether genetic propensity for late-life onset psychosis is shared with other traits. We aimed to elucidate the shared genetic liability between Educational Attainment, Intelligence, Reasoning, Memory, Neuroticism, Alzheimer's Disease, Major Depression, Schizophrenia and Bipolar Disorder and Mild Behavioral Impairment (MBI)-Psychosis in later life.
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