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Mortality reduction with 23-valent pneumococcal polysaccharide vaccine: a systematic review and meta-analysis.
Pneumonia (Nathan)
December 2024
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Background: Pneumococcal disease, caused by Streptococcus pneumoniae, imposes a significant global health burden, particularly affecting vulnerable groups such as the elderly and immunocompromised. The 23-valent pneumococcal polysaccharide vaccine (PPV23) is designed to protect against 23 serotypes of Streptococcus pneumoniae. However, there is ongoing debate about its effectiveness in reducing all-cause mortality.
View Article and Find Full Text PDFPrimary Versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit.
Thromb Haemost
December 2024
McMaster University, Hamilton, Canada.
The McMaster Immune Thrombocytopenia (ITP) Summit was an educational seminar from leading experts in immune thrombocytopenia and related disorders geared towards hematologists, internists, immunologists, and clinical and translational scientists. The focus of the Summit was to review the mechanisms, diagnosis and treatment of primary versus secondary ITP. Specific objectives were to describe the unique features of secondary ITP, and to review its mechanisms in the context of autoimmune disease and infection.
View Article and Find Full Text PDFAmino Acid Quantification from Maize Tissues.
Cold Spring Harb Protoc
December 2024
Christopher S. Bond Life Sciences Center, Division of Biological Sciences, Interdisciplinary Plant Group, University of Missouri, Columbia, Missouri 65211, USA
Amino acid analysis is a vital part of analytical biochemistry. The increasing demand for low nitrogen fertilization and for plant-based diets with balanced amino acid levels and composition have made it crucial to develop reliable, fast, and affordable methods for analyzing amino acids in plants. As maize accounts for 43% of global cereal production, improving the amino acid composition of its kernels (i.
View Article and Find Full Text PDFProgress and Gaps in Respiratory Disease Research and Treatment: Highlights of the IRM 2024 in Shanghai.
J Respir Biol Transl Med
December 2024
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Respiratory diseases pose a major public health challenge globally, necessitating collaborative efforts between basic researchers and clinicians for effective solutions. China, which is heavily impacted by a broad spectrum of respiratory disorders, has made notable strides in both research and clinical management of these diseases. The International Respiratory Medicine (IRM) meeting was organized with the primary goal of facilitating the exchange of recent research developments and promoting collaboration between Chinese and American scientists in both basic and clinical research fields.
View Article and Find Full Text PDFStructure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
J Med Chem
December 2024
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria through human studies with DSM265, but currently no drugs against this target are in clinical use. We used structure-based computational tools including free energy perturbation (FEP+) to discover highly ligand efficient, potent, and selective pyrazole-based DHODH inhibitors through a scaffold hop from a pyrrole-based series.
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