This study introduces the ortho-diphenylphosphanylbenzoate (o-DPPB)/o-DPPB oxide system as a switchable directing/nondirecting leaving group in a copper-mediated allylic substitution with Grignard and organozinc reagents. With this system, the regioselective, stereospecific, and stereodivergent construction of quaternary as well as tertiary carbon centers is possible in a reliable and predictable fashion. Starting from one substrate enantiomer, both optical antipodes of the substitution products are readily available. Hence, this methodology features reversed polarity in comparison to established enolate alkylation chemistry and may be an interesting alternative, particularly for the construction of quaternary stereogenic carbon centers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/asia.200600100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Isolation of a Novel Bacterium Isolate Capable of Utilizing Crude Oil and Diesel Oil Spills as a Biological Bioremediation Agent.
Front Biosci (Elite Ed)
October 2024
Department of Environmental Biotechnology, Biotechnology Research Center, Al-Nahrain University, 10018 Baghdad, Iraq.
Background: Contamination with crude oil and hydrocarbons has become a global threat. Such threats have urged us to invent solutions to deal with this dilemma. However, chemical treatment comes with limited benefits.
View Article and Find Full Text PDFCytoprotective Effects and Intranuclear Localization of Sulfur-Containing Derivative of Buckminsterfullerene.
Front Biosci (Landmark Ed)
December 2024
Research Centre for Medical Genetics, 115522 Moscow, Russia.
Background: There is a growing interest in exploring the biological characteristics of nanoparticles and exploring their potential applications. However, there is still a lack of research into the potential genotoxicity of fullerene derivatives and their impact on gene expression in human cells. In this study, we investigated the effects of a water-soluble fullerene derivative, C60[C6H4SCH2COOK]5H (F1), on human embryonic lung fibroblasts (HELF).
View Article and Find Full Text PDFAlkaline Hydrogen Evolution Reaction Electrocatalysts for Anion Exchange Membrane Water Electrolyzers: Progress and Perspective.
JACS Au
December 2024
Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials, Institute of New Energy for Vehicles, School of Materials Science and Engineering, Tongji University, 201804, Shanghai, China.
For the aim of achieving the carbon-free energy scenario, green hydrogen (H) with non-CO emission and high energy density is regarded as a potential alternative to traditional fossil fuels. Over the last decades, significant breakthroughs have been realized on the alkaline hydrogen evolution reaction (HER), which is a fundamental advancement and efficient process to generate high-purity H in the laboratory. Based on this, the development of the practical industry-oriented anion exchange membrane water electrolyzer (AEMWE) is on the rise, showing competitiveness with the incumbent megawatt-scale H production technologies.
View Article and Find Full Text PDFSequential Pore Functionalization in MOFs for Enhanced Carbon Dioxide Capture.
JACS Au
December 2024
Materials Discovery Laboratory (MaD Lab), Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.
The capture of carbon dioxide (CO) is crucial for reducing greenhouse emissions and achieving net-zero emission goals. Metal-organic frameworks (MOFs) present a promising solution for carbon capture due to their structural adaptability, tunability, porosity, and pore modification. In this research, we explored the use of a copper (Cu(II))-based MOF called .
View Article and Find Full Text PDFRole of NaCO as Nucleation Seeds to Accelerate the CO Uptake Kinetics of MgO-Based Sorbents.
JACS Au
December 2024
Laboratory of Energy Science and Engineering, Department of Mechanical and Process Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, 8092 Zürich, Switzerland.
There is an urgent need for inexpensive, functional materials that can capture and release CO under industrial conditions. In this context, MgO is a highly promising, earth-abundant CO sorbent. However, despite its favorable carbonation thermodynamics and potential for high gravimetric CO uptakes, MgO-based CO sorbents feature slow carbonation kinetics, limiting their CO uptake during typical industrial contact times.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!