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Enhanced antibody responses in CD19-Cre mice.
Sci Rep
January 2025
Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku, Finland.
CD19-Cre is an important and widely used Cre-lox model for B cell-specific genetic manipulation in murine systems. Mice carrying one allele of CD19-Cre are, at the same time, rendered heterozygote for CD19, a crucial coreceptor of the B cell antigen receptor (BCR). As a result, CD19-Cre mice exhibit diminished expression levels of CD19, with potential, yet insufficiently examined, consequences in B cell activation.
View Article and Find Full Text PDFAnti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection.
bioRxiv
November 2024
UCLA AIDS Institute, UCLA, Los Angeles, CA, USA, 90024.
Article Synopsis
- HSPC-based gene therapy shows potential for long-term HIV-1 remission after a single treatment, using a lentiviral vector to deliver three anti-HIV-1 genes.
- Two of the genes focus on preventing infection by targeting the CCR5 co-receptor and inhibiting fusion of the virus, while the third gene is designed to attack infected cells.
- The therapy was successful in humanized mouse models, significantly reducing HIV-1 viral load and allowing for safe removal of modified cells if necessary, demonstrating both effectiveness and safety of the approach.
Preventing Inappropriate Signals Pre- and Post-Ligand Perception by a Toggle-Switch Mechanism of ERECTA.
bioRxiv
September 2024
Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712 USA.
Article Synopsis
- The study focuses on the Arabidopsis ERECTA (ER) receptor kinase, which regulates various developmental processes through receptor signaling.
- The C-terminal tail of the ER receptor (ER_CT) acts as an autoinhibitory element that prevents excessive receptor activity, and its removal leads to increased kinase activity during plant growth.
- Phosphorylation of ER_CT by the co-receptor BAK1 alters its structure, affecting interactions with inhibitors and ligases, thus enabling precise control over receptor activation and ensuring quick deactivation after signaling.
Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila.
Cell Rep
August 2024
Department of Biology, The University of Vermont, Burlington, VT 05405, USA. Electronic address:
Chemosensory cells across the body of Drosophila melanogaster evaluate the environment to prioritize certain behaviors. Previous mapping of gustatory receptor neurons (GRNs) on the fly labellum identified a set of neurons in L-type sensilla that express Ionotropic Receptor 94e (IR94e), but the impact of IR94e GRNs on behavior remains unclear. We used optogenetics and chemogenetics to activate IR94e neurons and found that they drive mild feeding suppression but enhance egg laying.
View Article and Find Full Text PDFCo-Infections and Superinfections between HIV-1 and Other Human Viruses at the Cellular Level.
Pathogens
April 2024
Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Co-infection or superinfection of the host by two or more virus species is a common event, potentially leading to viral interference, viral synergy, or neutral interaction. The simultaneous presence of two or more viruses, even distantly related, within the same cell depends upon viral tropism, i.e.
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