The present study investigates the effects of surfactants (<0.01% v/v) on the size and hydrolytic stability of poly(adipic anhydride) (pAA) micro- and nanospheres fabricated using a modified phase inversion technique. Overall, surfactants increased the output yield by roughly 20%. Lecithin produced the greatest reduction in the volumetric particle size (dvol) compared to particles fabricated with no surfactant (dvol = 530 +/- 300 nm and 2.2 +/- 1.1 microm, respectively). In addition, sorbitan monooleate produced spheres with smaller numeric diameters (dnum) than the control but appeared to induce aggregation (dvol = 7.7 +/- 12.5 microm). The dnum and dvol were not dependent on the hydrophobicity of the surfactant (R2 = 0.36 and 0.03, respectively) or the apparent surface tension of the non-solvent (NS) phase (R2 = 0.44 and 0.04, respectively). In addition, quantitative DSC and FT-IR analysis confirmed that altering the particle size could also influence the hydrolytic stability of pAA.
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